Rapgef4 - Rap guanine nucleotide exchange factor 4 Gene

Rattus norvegicus

Also known as CAMPS; Cgef2; Epac2; CAMP-GEFII

Gene ID: 252857 | Gene type: protein coding

About Rapgef4

Summary

Enables cAMP binding activity and guanyl-nucleotide exchange factor activity. Involved in several processes, including animal organ development; positive regulation of neuronal action potential; and regulation of neurotransmitter receptor localization to postsynaptic specialization membrane. Located in several cellular components, including basolateral plasma membrane; brush border; and distal axon. Part of protein-containing complex. Is active in glutamatergic synapse and postsynaptic density. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human RAPGEF4 (Rap guanine nucleotide exchange factor 4). [provided by Alliance of Genome Resources, Apr 2022]

Rapgef4 Products(2)

mRNA	Protein	Name
NM_001100642.1	NP_001094112.1	rap guanine nucleotide exchange factor 4
NM_001100642.1	NP_001094112.1	rap guanine nucleotide exchange factor 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cAMP binding	IDA IDA: Inferred from direct assay	9856955	RGD
enables guanyl-nucleotide exchange factor activity	IDA IDA: Inferred from direct assay	9856955	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	15202935	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	19734897	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to nerve growth factor stimulus	IEP IEP: Inferred from expression pattern	25126967	RGD
involved in ganglion development	IEP IEP: Inferred from expression pattern	18583150	RGD
involved in heart development	IEP IEP: Inferred from expression pattern	18697745	RGD
involved in negative regulation of synaptic transmission	IDA IDA: Inferred from direct assay	19734897	RGD
involved in positive regulation of neuronal action potential	IMP IMP: Inferred from mutant phenotype	25126967	RGD
involved in positive regulation of protein secretion	IMP IMP: Inferred from mutant phenotype	25126967	RGD
involved in positive regulation of smooth muscle cell migration	IDA IDA: Inferred from direct assay	18697745	RGD
involved in regulation of dendrite development	IMP IMP: Inferred from mutant phenotype	19734897	RGD
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IDA IDA: Inferred from direct assay	19734897	RGD
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IMP IMP: Inferred from mutant phenotype	19734897	RGD
involved in regulation of postsynapse organization	IDA IDA: Inferred from direct assay	19734897	RGD
involved in regulation of postsynapse organization	IMP IMP: Inferred from mutant phenotype	19734897	RGD
involved in response to benzene	IEP IEP: Inferred from expression pattern	15468289	RGD
involved in spinal cord development	IEP IEP: Inferred from expression pattern	18583150	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	18495799	RGD
located in axon	IDA IDA: Inferred from direct assay	19734897	RGD
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	18495799	RGD
located in brush border	IDA IDA: Inferred from direct assay	18495799	RGD
located in cone cell pedicle	IDA IDA: Inferred from direct assay	19883736	RGD
located in dendrite	IDA IDA: Inferred from direct assay	19734897	RGD
located in dendritic spine	IDA IDA: Inferred from direct assay	19734897	RGD
located in excitatory synapse	IDA IDA: Inferred from direct assay	19734897	RGD
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	19734897	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	19734897	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	19734897	RGD
located in growth cone	IDA IDA: Inferred from direct assay	18583150	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	19883736	RGD
located in photoreceptor inner segment	IDA IDA: Inferred from direct assay	19883736	RGD
located in photoreceptor outer segment	IDA IDA: Inferred from direct assay	19883736	RGD
is active in postsynaptic density	IDA IDA: Inferred from direct assay	19734897	RGD
is active in presynapse	EXP EXP: Inferred from Experiment	19734897	RGD
is active in presynapse	IDA IDA: Inferred from direct assay	19734897	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	19734897	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

rap guanine nucleotide exchange factor 4

Rap guanine nucleotide exchange factor (GEF) 4	cAMP-regulated guanine nucleotide exchange factor II
epac 2	exchange factor directly activated by cAMP 2
exchange protein directly activated by cAMP 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11663	RAPGEF4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21252	Rapgef4 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS27769	Rapgef4 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rapgef4	NCBI	NCBI:11069

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