Dspp - dentin sialophosphoprotein Gene

Rattus norvegicus

Also known as Dsp; RDSP2

Gene ID: 25254 | Gene type: protein coding

About Dspp

Summary

Enables Collagen binding activity. Involved in several processes, including animal organ development; cellular response to dexamethasone stimulus; and odontoblast differentiation. Acts upstream of or within positive regulation of calcium ion import. Located in several cellular components, including collagen-containing extracellular matrix; nucleus; and plasma membrane. Biomarker of osteoporosis. Human ortholog(s) of this gene implicated in dentinogenesis imperfecta. Orthologous to human DSPP (dentin sialophosphoprotein). [provided by Alliance of Genome Resources, Apr 2022]

Dspp Products(1)

mRNA	Protein	Name
NM_012790.3	NP_036922.3	dentin sialophosphoprotein precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables collagen binding	IDA IDA: Inferred from direct assay	22615197	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	23525114	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in biomineral tissue development	IEP IEP: Inferred from expression pattern	20425127	RGD
involved in cartilage development	IEP IEP: Inferred from expression pattern	20679519	RGD
involved in cell differentiation	IEP IEP: Inferred from expression pattern	15308669	RGD
involved in cellular response to dexamethasone stimulus	IEP IEP: Inferred from expression pattern	20666749	RGD
involved in cellular response to hormone stimulus	IEP IEP: Inferred from expression pattern	22946647	RGD
involved in dentinogenesis	IEP IEP: Inferred from expression pattern	24502800	RGD
involved in hair follicle maturation	IEP IEP: Inferred from expression pattern	21908176	RGD
involved in mandibular condyle articular cartilage development	IEP IEP: Inferred from expression pattern	20097540	RGD
involved in odontoblast differentiation	IEP IEP: Inferred from expression pattern	15763925	RGD
involved in odontogenesis of dentin-containing tooth	IEP IEP: Inferred from expression pattern	15533758	RGD
acts upstream of or within positive regulation of calcium ion import	IDA IDA: Inferred from direct assay	23525114	RGD
involved in regulation of odontoblast differentiation	IDA IDA: Inferred from direct assay	15308669	RGD
involved in response to carbohydrate	IEP IEP: Inferred from expression pattern	20088703	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	24661255	RGD
involved in response to mechanical stimulus	IEP IEP: Inferred from expression pattern	22342686	RGD
involved in response to transforming growth factor beta	IEP IEP: Inferred from expression pattern	22012415	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in collagen-containing extracellular matrix	IDA IDA: Inferred from direct assay	16776771	RGD
located in nucleus	IDA IDA: Inferred from direct assay	23525114	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	23525114	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

dentin sialophosphoprotein

Dentin sialoprotein	Dentine sialoprotein
dentin sailophosphoprotein

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P3386A	Selcopintide acetate		99.83%	Unkown
HY-P3386	Selcopintide		/	Unkown
HY-RS04027	DSPP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21329	Dspp Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS27848	Dspp Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dspp	NCBI	NCBI:1834

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