Htr2c - 5-hydroxytryptamine receptor 2C Gene

Rattus norvegicus

Also known as 5-HT2C; 5HT-1C; 5-HTR2C

Gene ID: 25187 | Gene type: protein coding

About Htr2c

Summary

Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate Phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter Amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of Phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in rodents show altered patterns of RNA editing in response to drug treatments and stressful situations. [provided by RefSeq, Jul 2008]

Htr2c Products(1)

mRNA	Protein	Name
NM_012765.3	NP_036897.2	5-hydroxytryptamine receptor 2C

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables G protein-coupled serotonin receptor activity	IMP IMP: Inferred from mutant phenotype	15663485	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	16474401	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in animal organ regeneration	IEP IEP: Inferred from expression pattern	17258772	RGD
involved in behavioral response to nicotine	IMP IMP: Inferred from mutant phenotype	17473916	RGD
involved in feeding behavior	IMP IMP: Inferred from mutant phenotype	15705738	RGD
involved in negative regulation of dopamine metabolic process	IMP IMP: Inferred from mutant phenotype	17018023	RGD
involved in phospholipase C-activating serotonin receptor signaling pathway	IDA IDA: Inferred from direct assay	12435801	RGD
involved in phospholipase D-activating G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	12435801	RGD
involved in positive regulation of acetylcholine secretion, neurotransmission	IMP IMP: Inferred from mutant phenotype	15266551	RGD
involved in positive regulation of gamma-aminobutyric acid secretion	IMP IMP: Inferred from mutant phenotype	17043669	RGD
involved in positive regulation of vasoconstriction	IMP IMP: Inferred from mutant phenotype	15118345	RGD
involved in response to xenobiotic stimulus	IMP IMP: Inferred from mutant phenotype	16807362	RGD
involved in sensitization	IMP IMP: Inferred from mutant phenotype	20814782	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	15663485	RGD
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	1373499	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

5-hydroxytryptamine receptor 2C

5-HT-1C	5-HT1C
5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled	5-hydroxytryptamine receptor 1C
serotonin 1c receptor	serotonin receptor 2C

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06469	HTR2C Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20957	Htr2c Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27474	Htr2c Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Htr2c	NCBI	NCBI:3358

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