2. Gene
  3. GATA1 - Gata1 GATA binding protein 1 Gene

GATA1 - Gata1 GATA binding protein 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Eryf1

Gene ID: 25172 | Gene type: protein coding

About GATA1

Summary

Enables chromatin binding activity and sequence-specific DNA binding activity. Involved in several processes, including Sertoli cell development; cellular response to cAMP; and cellular response to follicle-stimulating hormone stimulus. Located in nucleus. Biomarker of mental depression and polycythemia. Human ortholog(s) of this gene implicated in several diseases, including Down syndrome; X-linked recessive disease (multiple); bone marrow Cancer (multiple); colon adenocarcinoma; and myeloid leukemia associated with Down Syndrome. Orthologous to human GATA1 (GATA binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]

GATA1 Products(1)

mRNA Protein Name
NM_012764.2 NP_036896.1 erythroid transcription factor
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables DNA binding IDA
IDA: Inferred from direct assay
7957872 RGD
enables chromatin binding IDA
IDA: Inferred from direct assay
22885997 RGD
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
7957872 RGD
Biological Process GO Annotation Evidence Reference Source
involved in Sertoli cell development IEP
IEP: Inferred from expression pattern
9089398 RGD
involved in animal organ regeneration IDA
IDA: Inferred from direct assay
18990226 RGD
involved in cellular response to cAMP IEP
IEP: Inferred from expression pattern
11861504 RGD
involved in cellular response to follicle-stimulating hormone stimulus IEP
IEP: Inferred from expression pattern
11861504 RGD
involved in cellular response to lipopolysaccharide IDA
IDA: Inferred from direct assay
17687519 RGD
involved in positive regulation of cytosolic calcium ion concentration IMP
IMP: Inferred from mutant phenotype
22390417 RGD
involved in positive regulation of mast cell degranulation IMP
IMP: Inferred from mutant phenotype
22390417 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

erythroid transcription factor

GATA-1

GATA-binding factor 1

GATA-binding protein 1 (globin transcription factor 1)

GF-1

NF-E1 DNA-binding protein

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05289 GATA1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS20026 Gata1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS26529 Gata1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens GATA1 NCBI NCBI:2623