2. Gene
  3. Cdkn2a - cyclin-dependent kinase inhibitor 2A Gene

Cdkn2a - cyclin-dependent kinase inhibitor 2A Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Arf; p16; MTS1; INK4A; p19ARF; p16Cdkn2a

Gene ID: 25163 | Gene type: protein coding

About Cdkn2a

Summary

Predicted to enable several functions, including MDM2/MDM4 family protein binding activity; NF-kappaB binding activity; and enzyme inhibitor activity. Involved in several processes, including cellular response to glucose stimulus; negative regulation of hepatocyte proliferation; and nervous system development. Located in cytoplasm and nucleus. Used to study carcinoma (multiple); endometrial cancer; pre-malignant neoplasm; rhabdomyosarcoma; and sarcomatoid mesothelioma. Biomarker of hepatocellular carcinoma; hypertension; obesity; and osteoarthritis. Human ortholog(s) of this gene implicated in several diseases, including breast Cancer (multiple); hematologic Cancer (multiple); melanoma (multiple); nervous system Cancer (multiple); and pancreatic Cancer (multiple). Orthologous to human CDKN2A (cyclin dependent kinase inhibitor 2A). [provided by Alliance of Genome Resources, Apr 2022]

Cdkn2a Products(1)

mRNA Protein Name
NM_031550.2 NP_113738.1 cyclin-dependent kinase inhibitor 2A
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to glucose stimulus IEP
IEP: Inferred from expression pattern
20943765 RGD
involved in cerebellum development IEP
IEP: Inferred from expression pattern
9693786 RGD
involved in negative regulation of hepatocyte proliferation IMP
IMP: Inferred from mutant phenotype
24190239 RGD
involved in neurogenesis IEP
IEP: Inferred from expression pattern
19114593 RGD
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
22020338 RGD
involved in response to caloric restriction IEP
IEP: Inferred from expression pattern
15520862 RGD
involved in response to fatty acid IEP
IEP: Inferred from expression pattern
22395468 RGD
involved in response to organic cyclic compound IDA
IDA: Inferred from direct assay
18204080 RGD
involved in response to salt stress IEP
IEP: Inferred from expression pattern
19826180 RGD
involved in response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
17706854 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
12189186 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cyclin-dependent kinase inhibitor 2A

CDK4I

Cyclin dependent kinase inhibitor 2A (p16, inhibits CDK4)

alternative reading frame

cell cycle inhibitor

cell cycle regulator

cyclin-dependent kinase 4 inhibitor A

cyclin-dependent kinase inhibitor 2a p16Ink4a

cyclin-dependent kinase inhibito

Related Agents

Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-119344 MS37452 Inhibitor 99.81% Unkown
HY-138684 MRTX9768 Inhibitor 99.60% Unkown
HY-138684A MRTX9768 hydrochloride Inhibitor 99.88% Unkown
HY-RS02414 CDKN2A Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS16723 Cdkn2a Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23159 Cdkn2a Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cdkn2a NCBI NCBI:1029