Igf2r - insulin-like growth factor 2 receptor Gene

Rattus norvegicus

Also known as Igfr2; IGF-IIR

Gene ID: 25151 | Gene type: protein coding

About Igf2r

Summary

Enables several functions, including G-protein alpha-subunit binding activity; insulin-like growth factor II binding activity; and retinoic acid binding activity. Involved in several processes, including animal organ regeneration; response to retinoic acid; and response to tetrachloromethane. Located in several cellular components, including extracellular space; late endosome; and perinuclear region of cytoplasm. Part of clathrin coat. Colocalizes with trans-Golgi network. Used to study lung adenocarcinoma. Biomarker of amyotrophic lateral sclerosis. Human ortholog(s) of this gene implicated in diabetes mellitus (multiple); hepatocellular carcinoma; in situ carcinoma (multiple); and nephroblastoma. Orthologous to human IGF2R (Insulin like growth factor 2 receptor). [provided by Alliance of Genome Resources, Apr 2022]

Igf2r Products(1)

mRNA	Protein	Name
NM_012756.2	NP_036888.2	cation-independent mannose-6-phosphate receptor precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables G-protein alpha-subunit binding	IDA IDA: Inferred from direct assay	16407557	RGD
enables enzyme binding	IDA IDA: Inferred from direct assay	11247783	RGD
enables insulin-like growth factor II binding	IDA IDA: Inferred from direct assay	16407557	RGD
enables retinoic acid binding	IDA IDA: Inferred from direct assay	10470859	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	19095737	RGD
involved in animal organ regeneration	IEP IEP: Inferred from expression pattern	12547403	RGD
involved in liver development	IDA IDA: Inferred from direct assay	12127995	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	19095737	RGD
involved in post-embryonic development	IEP IEP: Inferred from expression pattern	18824840	RGD
involved in regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	16825605	RGD
involved in response to retinoic acid	IDA IDA: Inferred from direct assay	9811861	RGD
involved in response to tetrachloromethane	IEP IEP: Inferred from expression pattern	9632637	RGD
involved in spermatogenesis	IEP IEP: Inferred from expression pattern	10993842	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of clathrin coat	IDA IDA: Inferred from direct assay	2971973	RGD
located in endosome	IDA IDA: Inferred from direct assay	15033478	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	10470859	RGD
located in late endosome	IDA IDA: Inferred from direct assay	19337031	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	15033478	RGD
located in trans-Golgi network	IDA IDA: Inferred from direct assay	15033478	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

cation-independent mannose-6-phosphate receptor

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06622	IGF2R Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17981	Igf2r Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24452	Igf2r Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Igf2r	NCBI	NCBI:3482

Name
Email *

	Sorry, but the email address you supplied was invalid.