Cyp17a1 - cytochrome P450, family 17, subfamily a, polypeptide 1 Gene

Rattus norvegicus

Also known as Cyp17

Gene ID: 25146 | Gene type: protein coding

About Cyp17a1

Summary

Enables steroid 17-alpha-monooxygenase activity. Involved in several processes, including animal organ development; response to fungicide; and response to Herbicide. Located in cell projection; endoplasmic reticulum; and neuronal cell body. Biomarker of sciatic neuropathy. Human ortholog(s) of this gene implicated in several diseases, including cholelithiasis; congenital adrenal hyperplasia; gallbladder cancer; osteoporosis; and prostate Cancer. Orthologous to human CYP17A1 (Cytochrome P450 family 17 subfamily A member 1). [provided by Alliance of Genome Resources, Apr 2022]

Cyp17a1 Products(1)

mRNA	Protein	Name
NM_012753.3	NP_036885.2	steroid 17-alpha-hydroxylase/17,20 lyase precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables steroid 17-alpha-monooxygenase activity	IDA IDA: Inferred from direct assay	2786990	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in Leydig cell differentiation	IEP IEP: Inferred from expression pattern	18502897	RGD
involved in adrenal gland development	IEP IEP: Inferred from expression pattern	17065412	RGD
involved in biphenyl metabolic process	IEP IEP: Inferred from expression pattern	20356859	RGD
involved in cellular response to antibiotic	IEP IEP: Inferred from expression pattern	18655822	RGD
involved in cellular response to gonadotropin stimulus	IEP IEP: Inferred from expression pattern	20963569	RGD
involved in cellular response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	20665543	RGD
involved in dibenzo-p-dioxin metabolic process	IEP IEP: Inferred from expression pattern	20059580	RGD
involved in hippocampus development	IEP IEP: Inferred from expression pattern	21047951	RGD
involved in male gonad development	IEP IEP: Inferred from expression pattern	10822021	RGD
involved in organic acid metabolic process	IEP IEP: Inferred from expression pattern	17400581	RGD
involved in phenol-containing compound metabolic process	IEP IEP: Inferred from expression pattern	18191889	RGD
involved in phthalate metabolic process	IEP IEP: Inferred from expression pattern	16809437	RGD
involved in positive regulation of steroid hormone biosynthetic process	IMP IMP: Inferred from mutant phenotype	19615041	RGD
involved in response to acetate	IEP IEP: Inferred from expression pattern	21046364	RGD
involved in response to cAMP	IEP IEP: Inferred from expression pattern	17291543	RGD
involved in response to cytokine	IEP IEP: Inferred from expression pattern	15958400	RGD
involved in response to fungicide	IEP IEP: Inferred from expression pattern	16214947	RGD
involved in response to gonadotropin	IEP IEP: Inferred from expression pattern	17291543	RGD
involved in response to herbicide	IEP IEP: Inferred from expression pattern	20667998	RGD
involved in response to insecticide	IEP IEP: Inferred from expression pattern	17569032	RGD
involved in response to ionizing radiation	IEP IEP: Inferred from expression pattern	18821396	RGD
involved in response to methylmercury	IEP IEP: Inferred from expression pattern	17869401	RGD
involved in response to nutrient levels	IEP IEP: Inferred from expression pattern	17936465	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	18923996	RGD
involved in response to retinoic acid	IEP IEP: Inferred from expression pattern	19497980	RGD
involved in response to steroid hormone	IEP IEP: Inferred from expression pattern	19961867	RGD
involved in response to toxic substance	IEP IEP: Inferred from expression pattern	17291543	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	19603415	RGD
involved in steroid biosynthetic process	IMP IMP: Inferred from mutant phenotype	2786990	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell projection	IDA IDA: Inferred from direct assay	15934942	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	15934942	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

steroid 17-alpha-hydroxylase/17,20 lyase

17-alpha-hydroxyprogesterone aldolase	CYPXVII
Cytochrome P450, subfamily XVII	P450-C17
P45017alpha	P450c17
cytochrome P450 17A1	cytochrome P450, subfamily 17
cytochrome P450-C17	cytochrome P450c17
steroid 17-alpha-monooxygenase

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-163359	CYP17A1/HDAC6-IN-1	Inhibitor	/	Unkown
HY-164457	ASN-001	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cyp17a1	NCBI	NCBI:1586

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