Stat1 - signal transducer and activator of transcription 1 Gene

Rattus norvegicus

Also known as DD6G4-4

Gene ID: 25124 | Gene type: protein coding

About Stat1

Summary

Enables CCR5 Chemokine Receptor binding activity; protein Phosphatase 2A binding activity; and sequence-specific DNA binding activity. Involved in several processes, including positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of smooth muscle cell proliferation; and receptor signaling pathway via JAK-STAT. Acts upstream of or within cellular response to cytokine stimulus and cellular response to organic cyclic compound. Located in several cellular components, including axon; dendrite; and nucleus. Used to study pulmonary fibrosis. Human ortholog(s) of this gene implicated in breast carcinoma; immunodeficiency 31A; immunodeficiency 31B; immunodeficiency 31C; and prostate adenocarcinoma. Orthologous to human STAT1 (signal transducer and activator of transcription 1). [provided by Alliance of Genome Resources, Apr 2022]

Stat1 Products(2)

mRNA	Protein	Name
NM_001034164.1	NP_001029336.1	signal transducer and activator of transcription 1-alpha/beta isoform beta
NM_032612.3	NP_116001.2	signal transducer and activator of transcription 1-alpha/beta isoform alpha

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables CCR5 chemokine receptor binding	IPI IPI: Inferred from physical interaction	14674010	RGD
enables DNA binding	IDA IDA: Inferred from direct assay	7519422	RGD
enables protein phosphatase 2A binding	IPI IPI: Inferred from physical interaction	17084018	RGD
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	16648019	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in blood circulation	IMP IMP: Inferred from mutant phenotype	17361215	RGD
involved in cell surface receptor signaling pathway via JAK-STAT	IMP IMP: Inferred from mutant phenotype	12191995	RGD
acts upstream of or within cellular response to cytokine stimulus	IDA IDA: Inferred from direct assay	19414010	RGD
involved in cellular response to insulin stimulus	IDA IDA: Inferred from direct assay	15749807	RGD
acts upstream of or within cellular response to organic cyclic compound	IDA IDA: Inferred from direct assay	19414010	RGD
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	15948243	RGD
involved in positive regulation of nitric-oxide synthase biosynthetic process	IMP IMP: Inferred from mutant phenotype	22788969	RGD
involved in positive regulation of smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	17293493	RGD
involved in response to cAMP	IDA IDA: Inferred from direct assay	9144559	RGD
involved in response to cytokine	IDA IDA: Inferred from direct assay	17694433	RGD
involved in response to hydrogen peroxide	IEP IEP: Inferred from expression pattern	17607690	RGD
involved in response to mechanical stimulus	IDA IDA: Inferred from direct assay	15350851	RGD
involved in response to nutrient	IDA IDA: Inferred from direct assay	15454281	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	18031608	RGD
involved in response to peptide hormone	IDA IDA: Inferred from direct assay	15749807	RGD
involved in response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	17293493	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	14642652	RGD
located in dendrite	IDA IDA: Inferred from direct assay	14642652	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

signal transducer and activator of transcription 1-alpha/beta

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-115594	Erasin	Inhibitor	96.02%	Unkown
HY-149209	LL-K8-22	Inhibitor	99.76%	Unkown
HY-156466	QL-1200186	Inhibitor	99.95%	Unkown
HY-122891	SB02024	Activator	99.70%	Unkown
HY-119956	Biflorin	Inhibitor	99.54%	Unkown
HY-170621	STAT1/3-IN-1	Inhibitor	/	Unkown
HY-169360	SD-436	Degrader	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Stat1	NCBI	NCBI:6772

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