2. Gene
  3. Adra2a - adrenoceptor alpha 2A Gene

Adra2a - adrenoceptor alpha 2A Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as RG20; CA2-47; RATRG20

Gene ID: 25083 | Gene type: protein coding

About Adra2a

Summary

Enables alpha2-adrenergic receptor activity. Involved in several processes, including glucose homeostasis; negative regulation of secretion by cell; and negative regulation of uterine smooth muscle contraction. Located in several cellular components, including axon terminus; neuronal cell body; and plasma membrane. Is active in GABA-ergic synapse and glutamatergic synapse. Is integral component of postsynaptic density membrane and integral component of presynaptic active zone membrane. Used to study anxiety disorder and mental depression. Biomarker of hypertension and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder and type 2 diabetes mellitus. Orthologous to human ADRA2A (adrenoceptor alpha 2A). [provided by Alliance of Genome Resources, Apr 2022]

Adra2a Products(1)

mRNA Protein Name
NM_012739.3 NP_036871.3 alpha-2A adrenergic receptor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables alpha2-adrenergic receptor activity IDA
IDA: Inferred from direct assay
1645350 RGD
Biological Process GO Annotation Evidence Reference Source
involved in DNA replication IMP
IMP: Inferred from mutant phenotype
15351511 RGD
involved in G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
19965390 RGD
involved in female pregnancy IMP
IMP: Inferred from mutant phenotype
19450576 RGD
involved in glucose homeostasis IMP
IMP: Inferred from mutant phenotype
19965390 RGD
involved in negative regulation of calcium ion-dependent exocytosis IMP
IMP: Inferred from mutant phenotype
19965390 RGD
involved in negative regulation of insulin secretion involved in cellular response to glucose stimulus IMP
IMP: Inferred from mutant phenotype
19965390 RGD
involved in negative regulation of uterine smooth muscle contraction IMP
IMP: Inferred from mutant phenotype
17664026 RGD
involved in response to alcohol IEP
IEP: Inferred from expression pattern
26121187 RGD
involved in response to morphine IEP
IEP: Inferred from expression pattern
9105684 RGD
involved in thermoception IDA
IDA: Inferred from direct assay
20110357 RGD
involved in vasodilation IDA
IDA: Inferred from direct assay
20837990 RGD
Cellular Component GO Annotation Evidence Reference Source
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
9596526 RGD
located in axon terminus IDA
IDA: Inferred from direct assay
12379250 RGD
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
9596526 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
9596526 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
12379250 RGD
is active in postsynaptic density membrane IDA
IDA: Inferred from direct assay
9596526 RGD
is active in postsynaptic membrane EXP
EXP: Inferred from Experiment
9596526 RGD
is active in postsynaptic membrane IDA
IDA: Inferred from direct assay
9596526 RGD
is active in presynaptic active zone membrane IDA
IDA: Inferred from direct assay
9596526 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

alpha-2A adrenergic receptor

adrenergic receptor, alpha 2a

adrenergic, alpha-2A-, receptor

alpha-2A adrenoceptor

alpha-2A adrenoreceptor

alpha-2AAR

alpha-2D adrenergic receptor

Related Agents

Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N8728 Aposcopolamine 98.44% Unkown
HY-145700 UCSF648 / Unkown
HY-163694 ADRA2A antagonist 1 Antagonist / Unkown
HY-RS00411 ADRA2A Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-134125 Yohimbic acid ethyl ester Antagonist / Unkown
HY-RS17718 Adra2a Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS24183 Adra2a Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Adra2a NCBI NCBI:150