Htr1b - 5-hydroxytryptamine receptor 1B Gene

Rattus norvegicus

Gene ID: 25075 | Gene type: protein coding

About Htr1b

Summary

Enables G protein-coupled serotonin receptor activity; heterocyclic compound binding activity; and voltage-gated Calcium Channel activity involved in regulation of presynaptic cytosolic calcium levels. Involved in several processes, including modulation of chemical synaptic transmission; regulation of amine transport; and response to cocaine. Located in plasma membrane. Is active in calyx of Held. Used to study anxiety disorder. Biomarker of hypertension; ischemia; and obesity. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder and conduct disorder. Orthologous to human HTR1B (5-hydroxytryptamine receptor 1B). [provided by Alliance of Genome Resources, Apr 2022]

Htr1b Products(1)

mRNA	Protein	Name
NM_022225.2	NP_071561.1	5-hydroxytryptamine receptor 1B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables G protein-coupled serotonin receptor activity	IDA IDA: Inferred from direct assay	15328035	RGD
enables heterocyclic compound binding	IDA IDA: Inferred from direct assay	16546225	RGD
enables voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels	EXP EXP: Inferred from Experiment	17067296	RGD
enables voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels	IDA IDA: Inferred from direct assay	17067296	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in chemical synaptic transmission	IDA IDA: Inferred from direct assay	15328035	RGD
involved in drinking behavior	IMP IMP: Inferred from mutant phenotype	16839853	RGD
involved in feeding behavior	IMP IMP: Inferred from mutant phenotype	12373419	RGD
involved in negative regulation of gamma-aminobutyric acid secretion	IDA IDA: Inferred from direct assay	30217553	RGD
involved in negative regulation of synaptic transmission, GABAergic	IMP IMP: Inferred from mutant phenotype	17229091	RGD
involved in negative regulation of synaptic transmission, glutamatergic	IMP IMP: Inferred from mutant phenotype	17392733	RGD
involved in presynaptic modulation of chemical synaptic transmission	EXP EXP: Inferred from Experiment	17067296	RGD
involved in presynaptic modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	17067296	RGD
involved in regulation of dopamine secretion	IMP IMP: Inferred from mutant phenotype	16885935	RGD
involved in regulation of synaptic vesicle exocytosis	EXP EXP: Inferred from Experiment	17067296	RGD
involved in regulation of synaptic vesicle exocytosis	IDA IDA: Inferred from direct assay	17067296	RGD
involved in response to cocaine	IDA IDA: Inferred from direct assay	17509084	RGD
involved in response to ethanol	IMP IMP: Inferred from mutant phenotype	16212943	RGD
involved in response to mineralocorticoid	IEP IEP: Inferred from expression pattern	11882579	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in calyx of Held	EXP EXP: Inferred from Experiment	17067296	RGD
is active in calyx of Held	IDA IDA: Inferred from direct assay	17067296	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

5-hydroxytryptamine receptor 1B

5-HT-1B	5-HT1B serotonin receptor
5-hydroxytryptamine (serotonin ) receptor 1B	5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
serotonin (5-hydroxytryptamine (5HT)) receptor type 1B	serotonin receptor 1B

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06461	HTR1B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20424	Htr1b Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26933	Htr1b Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Htr1b	NCBI	NCBI:3351

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