Hk1 - hexokinase 1 Gene

Rattus norvegicus

Also known as HKI; HEXOKIN

Gene ID: 25058 | Gene type: protein coding

About Hk1

Summary

Enables several functions, including ATP binding activity; glucose binding activity; and Hexokinase activity. Involved in several processes, including phosphorylation; response to ischemia; and response to ketamine. Located in caveola; cytosol; and mitochondrion. Part of protein-containing complex. Used to study obesity and urinary bladder Cancer. Biomarker of colorectal Cancer and pulmonary hypertension. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4G; anemia (multiple); hematologic Cancer (multiple); obesity; and retinitis pigmentosa. Orthologous to human HK1 (Hexokinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Hk1 Products(2)

mRNA	Protein	Name
NM_001393711.1	NP_001380640.1	hexokinase-1 isoform 1
NM_012734.2	NP_036866.2	hexokinase-1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IDA IDA: Inferred from direct assay	15562563	RGD
enables D-glucose binding	IDA IDA: Inferred from direct assay	9665168	RGD
enables fructokinase activity	IDA IDA: Inferred from direct assay	5871820	RGD
enables glucokinase activity	IDA IDA: Inferred from direct assay	5871820	RGD
enables hexokinase activity	IDA IDA: Inferred from direct assay	2457393	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	9665168	RGD
enables mannokinase activity	IDA IDA: Inferred from direct assay	13211595	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	16419038	RGD
enables protein kinase activity	IDA IDA: Inferred from direct assay	7531990	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	14561215	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in carbohydrate phosphorylation	IDA IDA: Inferred from direct assay	14561215	RGD
involved in fructose 6-phosphate metabolic process	IDA IDA: Inferred from direct assay	5871820	RGD
involved in glucose 6-phosphate metabolic process	IDA IDA: Inferred from direct assay	5871820	RGD
involved in glycolytic process	IDA IDA: Inferred from direct assay	4353083	RGD
involved in mannose metabolic process	IDA IDA: Inferred from direct assay	13211595	RGD
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	15574336	RGD
involved in peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	7531990	RGD
involved in peptidyl-threonine phosphorylation	IDA IDA: Inferred from direct assay	7531990	RGD
involved in peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	7531990	RGD
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	2059200	RGD
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	2059200	RGD
involved in regulation of anion channel activity	IDA IDA: Inferred from direct assay	14561215	RGD
involved in response to brassinosteroid	IEP IEP: Inferred from expression pattern	20570616	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	29676955	RGD
involved in response to ischemia	IDA IDA: Inferred from direct assay	21410437	RGD
involved in response to ketamine	IEP IEP: Inferred from expression pattern	22605548	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in caveola	IDA IDA: Inferred from direct assay	16419038	RGD
located in mitochondrion	IDA IDA: Inferred from direct assay	2457393	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	9459579	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

hexokinase-1

brain form hexokinase	hexokinase type I
hexokinase-A

Related Agents

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N6954	Garcinone C		99.66%	Unkown
HY-RS06192	HK1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS06287	HOOK1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS07100	KCNA4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS07373	KLK1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14138	TAC4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17121	Hk1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23566	Hk1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hk1	NCBI	NCBI:3098
Macaca fascicularis	Hk1	NCBI	NCBI:102145864
Mus musculus	Hk1	NCBI	NCBI:15275

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