Snap25 - synaptosome associated protein 25 Gene

Rattus norvegicus

Also known as SNAP-25B; SNAP-25a

Gene ID: 25012 | Gene type: protein coding

About Snap25

Summary

Synaptic vesicle membrane docking and fusion is mediated by SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) located on the vesicle membrane (v-SNAREs) and the target membrane (t-SNAREs). The assembled v-SNARE/t-SNARE complex consists of a bundle of four helices, one of which is supplied by v-SNARE and the Other three by t-SNARE. For t-SNAREs on the plasma membrane, the protein syntaxin supplies one helix and the protein encoded by this gene contributes the Other two. Therefore, this gene product is a presynaptic plasma membrane protein. It is essential for regulated exocytosis in neuronal cells. Alternative transcript variants encoding two different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2012]

Snap25 Products(3)

mRNA	Protein	Name
NM_001270575.1	NP_001257504.1	synaptosomal-associated protein 25 isoform a
NM_001270576.1	NP_001257505.1	synaptosomal-associated protein 25 isoform a
NM_030991.3	NP_112253.1	synaptosomal-associated protein 25 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables SNARE binding	IDA IDA: Inferred from direct assay	7553862	RGD
enables SNARE binding	IPI IPI: Inferred from physical interaction	7698987	RGD
enables calcium-dependent protein binding	IPI IPI: Inferred from physical interaction	12526776	RGD
enables myosin binding	IPI IPI: Inferred from physical interaction	16030255	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	9759724	RGD
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	11152476	RGD
enables syntaxin-1 binding	IDA IDA: Inferred from direct assay	7553862	RGD
enables syntaxin-1 binding	IPI IPI: Inferred from physical interaction	16030255	RGD
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	19077057	RGD
enables voltage-gated potassium channel activity	IDA IDA: Inferred from direct assay	16478442	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in SNARE complex assembly	IMP IMP: Inferred from mutant phenotype	9671503	RGD
involved in axonogenesis	IEP IEP: Inferred from expression pattern	15478103	RGD
involved in calcium ion-regulated exocytosis of neurotransmitter	IDA IDA: Inferred from direct assay	14980208	RGD
involved in endosomal transport	IDA IDA: Inferred from direct assay	16481393	RGD
involved in long-term memory	IMP IMP: Inferred from mutant phenotype	16870134	RGD
involved in neuron differentiation	IEP IEP: Inferred from expression pattern	24841827	RGD
involved in positive regulation of hormone secretion	IMP IMP: Inferred from mutant phenotype	15147232	RGD
involved in positive regulation of insulin secretion	IEP IEP: Inferred from expression pattern	15042624	RGD
involved in regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	21986494	RGD
involved in regulation of synapse assembly	IEP IEP: Inferred from expression pattern	15478103	RGD
involved in synaptic vesicle exocytosis	EXP EXP: Inferred from Experiment	8103915	RGD
involved in synaptic vesicle exocytosis	IDA IDA: Inferred from direct assay	8103915	RGD
involved in synaptic vesicle exocytosis	IEP IEP: Inferred from expression pattern	8103915	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of SNARE complex	IDA IDA: Inferred from direct assay	16030255	RGD
located in actin cytoskeleton	IDA IDA: Inferred from direct assay	10625663	RGD
located in axon	IDA IDA: Inferred from direct assay	10712642	RGD
located in axonal growth cone	IDA IDA: Inferred from direct assay	10712642	RGD
located in endosome	IDA IDA: Inferred from direct assay	16481393	RGD
is active in extrinsic component of presynaptic membrane	IDA IDA: Inferred from direct assay	15983999	RGD
located in filopodium	IDA IDA: Inferred from direct assay	10625663	RGD
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	8103915	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	8103915	RGD
located in growth cone	IDA IDA: Inferred from direct assay	16598260	RGD
located in lamellipodium	IDA IDA: Inferred from direct assay	10625663	RGD
located in neuron projection	IDA IDA: Inferred from direct assay	16598260	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	10625663	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	21986494	RGD
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	7698978	RGD
part of synaptobrevin 2-SNAP-25-syntaxin-1a complex	IDA IDA: Inferred from direct assay	7553862	RGD
part of synaptobrevin 2-SNAP-25-syntaxin-1a complex	IMP IMP: Inferred from mutant phenotype	9671503	RGD
part of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex	IDA IDA: Inferred from direct assay	7553862	RGD
part of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex	IDA IDA: Inferred from direct assay	19132534	RGD
part of voltage-gated potassium channel complex	IDA IDA: Inferred from direct assay	16478442	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

synaptosomal-associated protein 25

SNAP-25	SUP
super protein	synaptosomal-associated 25 kDa protein
synaptosomal-associated protein, 25 kDa

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13474	SNAP25 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17856	Snap25 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24325	Snap25 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Snap25	NCBI	NCBI:6616

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