2. Gene
  3. Gcg - glucagon Gene

Gcg - glucagon Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Glp1; GLP-1

Gene ID: 24952 | Gene type: protein coding

About Gcg

Summary

Enables Glucagon Receptor binding activity and hormone activity. Involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway; negative regulation of appetite; and response to L-arginine. Located in extracellular space. Human ortholog(s) of this gene implicated in Alzheimer's disease and prediabetes syndrome. Orthologous to human GCG (glucagon). [provided by Alliance of Genome Resources, Apr 2022]

Gcg Products(1)

mRNA Protein Name
NM_012707.3 NP_036839.2 pro-glucagon preproprotein
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables glucagon receptor binding IDA
IDA: Inferred from direct assay
12960094 RGD
enables hormone activity IDA
IDA: Inferred from direct assay
12960094 RGD
enables hormone activity IMP
IMP: Inferred from mutant phenotype
11557638 RGD
Biological Process GO Annotation Evidence Reference Source
involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
12960094 RGD
involved in negative regulation of appetite IMP
IMP: Inferred from mutant phenotype
11557638 RGD
involved in response to L-arginine IEP
IEP: Inferred from expression pattern
2182011 RGD
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
12876072 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

pro-glucagon

glucagon-like peptide-1

Related Agents

Approval
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-109528 Fomivirsen sodium Inhibitor ≥99.0% Unkown
HY-109556 Insulin Detemir Activator ≥95.0% Unkown
HY-118874 Oblimersen / Unkown
Clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-132596 Tivanisiran Inhibitor 92.62% Phase 3
HY-148100 Emapticap pegol Inhibitor / Phase 2
HY-P10031A SAR441255 TFA Agonist 99.65% Phase 1
HY-P10031 SAR441255 Agonist 99.77% Phase 1
Pre-clinical Phase
Bioactive Molecules (10)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-150738 ODN 2088 Antagonist 93.63% Unkown
HY-150217 CpG ODN 10101 94.06% Unkown
HY-150736 ODN 20844 Inhibitor 92.60% Unkown
HY-150748 ODN D-SL01 Agonist 99.94% Unkown
HY-148412 Monarsen Inhibitor / Unkown
HY-150213 ODN BW001 Inhibitor / Unkown
HY-P5074 GRPP (human) Agonist / Unkown
HY-RS05323 GCG Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS17156 Gcg Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23606 Gcg Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gcg NCBI NCBI:2641
Mus musculus Gcg NCBI NCBI:14526