2. Gene
  3. Klrk1 - killer cell lectin like receptor K1 Gene

Klrk1 - killer cell lectin like receptor K1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as NKG2D; Nkrp2

Gene ID: 24934 | Gene type: protein coding

About Klrk1

Summary

Predicted to enable several functions, including MHC class I protein binding activity; MHC class Ib receptor activity; and identical protein binding activity. Involved in positive regulation of apoptotic process; positive regulation of myeloid dendritic cell activation; and positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target. Located in cell surface. Used to study histiocytoma. Human ortholog(s) of this gene implicated in tropical spastic paraparesis. Orthologous to several human genes including KLRC4-KLRK1 (KLRC4-KLRK1 readthrough). [provided by Alliance of Genome Resources, Apr 2022]

Klrk1 Products(1)

mRNA Protein Name
NM_133512.2 NP_598196.1 NKG2-D type II integral membrane protein
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16323246 RGD
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
15048723 RGD
involved in positive regulation of myeloid dendritic cell activation IDA
IDA: Inferred from direct assay
17369187 RGD
involved in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IMP
IMP: Inferred from mutant phenotype
16323246 RGD
Cellular Component GO Annotation Evidence Reference Source
located in cell surface IDA
IDA: Inferred from direct assay
15048723 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

NKG2-D type II integral membrane protein

NK cell receptor D

NK lectin-like receptor

NKG2-D-activating NK receptor

NKLLR

NKR-P2, ortholog of human NKG2D

killer cell lectin-like receptor subfamily K, member 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07399 KLRK1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS17835 Klrk1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS24303 Klrk1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P990972 Azerutamig / Unkown
HY-P991003 Ingitamig Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Klrk1 NCBI NCBI:22914
Macaca fascicularis Klrk1 NCBI
Mus musculus Klrk1 NCBI NCBI:27007
Macaca mulatta Klrk1 NCBI