Slc22a1 - solute carrier family 22 member 1 Gene

Rattus norvegicus

Also known as Oct1; Orct1; Roct1

Gene ID: 24904 | Gene type: protein coding

About Slc22a1

Summary

Enables several functions, including cation transmembrane transporter activity; identical protein binding activity; and toxin transmembrane transporter activity. Involved in several processes, including Catecholamine transport; ion transmembrane transport; and toxin transport. Located in apical plasma membrane and basolateral plasma membrane. Is integral component of plasma membrane. Used to study acute kidney failure. Biomarker of asthma; extrahepatic cholestasis; and intrahepatic cholestasis. Orthologous to human SLC22A1 (solute carrier family 22 member 1). [provided by Alliance of Genome Resources, Apr 2022]

Slc22a1 Products(1)

mRNA	Protein	Name
NM_012697.1	NP_036829.1	solute carrier family 22 member 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables acetylcholine transmembrane transporter activity	IDA IDA: Inferred from direct assay	15817714	RGD
enables dopamine:sodium symporter activity	IDA IDA: Inferred from direct assay	9776363	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	18361503	RGD
enables monoamine transmembrane transporter activity	IDA IDA: Inferred from direct assay	8955087	RGD
enables neurotransmitter transmembrane transporter activity	IDA IDA: Inferred from direct assay	15662044	RGD
enables norepinephrine:sodium symporter activity	IDA IDA: Inferred from direct assay	9776363	RGD
enables organic cation transmembrane transporter activity	IDA IDA: Inferred from direct assay	7990927	RGD
enables quaternary ammonium group transmembrane transporter activity	IDA IDA: Inferred from direct assay	8955087	RGD
enables toxin transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	20477935	RGD
enables xenobiotic transmembrane transporter activity	IDA IDA: Inferred from direct assay	8955087	RGD
enables xenobiotic transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	20477935	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in acetylcholine transport	IDA IDA: Inferred from direct assay	15817714	RGD
involved in cellular detoxification	IMP IMP: Inferred from mutant phenotype	20477935	RGD
involved in dopamine transport	IDA IDA: Inferred from direct assay	9776363	RGD
involved in epinephrine transport	IDA IDA: Inferred from direct assay	9776363	RGD
involved in establishment or maintenance of transmembrane electrochemical gradient	IDA IDA: Inferred from direct assay	15817714	RGD
involved in metanephric proximal tubule development	IEP IEP: Inferred from expression pattern	30645697	RGD
involved in monoamine transport	IDA IDA: Inferred from direct assay	9776363	RGD
involved in monoatomic cation transmembrane transport	IDA IDA: Inferred from direct assay	7990927	RGD
involved in norepinephrine transport	IDA IDA: Inferred from direct assay	9776363	RGD
involved in organic cation transport	IDA IDA: Inferred from direct assay	7990927	RGD
involved in quaternary ammonium group transport	IDA IDA: Inferred from direct assay	9776363	RGD
involved in serotonin transport	IDA IDA: Inferred from direct assay	15662044	RGD
involved in xenobiotic transport	IDA IDA: Inferred from direct assay	8955087	RGD
involved in xenobiotic transport	IMP IMP: Inferred from mutant phenotype	20477935	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	15817714	RGD
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	7990927	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	12176030	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

solute carrier family 22 member 1

organic cation transporter 1

solute carrier family 22 (organic cation transporter), member 1

Slc22a1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Slc22a1	Q63089	Slc22a1	Rattus norvegicus	Q63089	GMS	21896487
Intra	Slc22a1	Q63089	Slc22a1	Rattus norvegicus	Q63089	FRET	21896487
Intra	Slc22a1	Q63089	oct1_oat1	Rattus norvegicus	EBI-5261357	Pull Down	21896487
Intra	Slc22a1	Q63089	Slc22a1	Rattus norvegicus	Q63089	Pull Down	21896487

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13061	SLC22A1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19841	Slc22a1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26339	Slc22a1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc22a1	NCBI	NCBI:6580

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