Clu - clusterin Gene

Rattus norvegicus

Also known as CLI; DAG; APOJ; SGP2; SP40; SGP-2; SP-40; Trpm2; Trpmb; TRPM-2; TRPM2B; RATTRPM2B

Gene ID: 24854 | Gene type: protein coding

About Clu

Summary

The protein encoded by this gene is a secreted chaperone that can under some stress conditions also be found in the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders.[provided by RefSeq, May 2011]

Clu Products(1)

mRNA	Protein	Name
NM_053021.3	NP_444180.3	clusterin precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11570883	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to growth factor stimulus	IEP IEP: Inferred from expression pattern	16038898	RGD
involved in endocrine pancreas development	IMP IMP: Inferred from mutant phenotype	16411126	RGD
involved in estrous cycle	IEP IEP: Inferred from expression pattern	11149574	RGD
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	15591223	RGD
involved in negative regulation of neuron apoptotic process	IGI IGI: Inferred from genetic interaction	23164821	RGD
involved in neuron projection morphogenesis	IMP IMP: Inferred from mutant phenotype	16038898	RGD
involved in positive regulation of cell differentiation	IMP IMP: Inferred from mutant phenotype	16411126	RGD
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	15591223	RGD
involved in positive regulation of gene expression	IGI IGI: Inferred from genetic interaction	23164821	RGD
involved in protein stabilization	IDA IDA: Inferred from direct assay	11570883	RGD
involved in response to light stimulus	IEP IEP: Inferred from expression pattern	11803476	RGD
involved in response to potassium ion	IEP IEP: Inferred from expression pattern	12782389	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in aggresome	IDA IDA: Inferred from direct assay	12799419	RGD
located in cytosol	IDA IDA: Inferred from direct assay	16038898	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	11570883	RGD
located in growth cone	IDA IDA: Inferred from direct assay	16038898	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	16038898	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

clusterin

dimeric acid glycoprotein	sulfated glycoprotein 2
testosterone repressed prostate message 2	testosterone-repressed prostate message
testostrone-repressed prostate message 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02848	CLU Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17319	Clu Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23774	Clu Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Clu	NCBI	NCBI:1191
Mus musculus	Clu	NCBI	NCBI:12759

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