Sod1 - superoxide dismutase 1 Gene

Rattus norvegicus

Also known as CuZnSOD

Gene ID: 24786 | Gene type: protein coding

About Sod1

Summary

Enables copper ion binding activity; protein Phosphatase 2B binding activity; and superoxide dismutase activity. Involved in several processes, including cellular response to metal ion; hydrogen peroxide biosynthetic process; and removal of superoxide radicals. Located in several cellular components, including dense core granule; mitochondrial intermembrane space; and neuronal cell body. Part of protein-containing complex. Used to study hyperthyroidism; hypothyroidism; middle cerebral artery infarction; and sciatic neuropathy. Biomarker of several diseases, including artery disease (multiple); congenital diaphragmatic hernia; middle cerebral artery infarction; non-alcoholic steatohepatitis; and ocular hypertension. Human ortholog(s) of this gene implicated in several diseases, including Down syndrome; artery disease (multiple); eye disease (multiple); glucose metabolism disease (multiple); and neurodegenerative disease (multiple). Orthologous to human SOD1 (superoxide dismutase 1). [provided by Alliance of Genome Resources, Apr 2022]

Sod1 Products(1)

mRNA	Protein	Name
NM_017050.1	NP_058746.1	superoxide dismutase [Cu-Zn]

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables copper ion binding	IMP IMP: Inferred from mutant phenotype	12514262	RGD
enables enzyme binding	IPI IPI: Inferred from physical interaction	23061969	RGD
enables protein phosphatase 2B binding	IDA IDA: Inferred from direct assay	17324120	RGD
enables superoxide dismutase activity	IDA IDA: Inferred from direct assay	2703531	RGD
enables superoxide dismutase activity	IMP IMP: Inferred from mutant phenotype	17324120	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to ATP	IEP IEP: Inferred from expression pattern	22572742	RGD
involved in cellular response to cadmium ion	IEP IEP: Inferred from expression pattern	17584760	RGD
involved in cellular response to oxidative stress	IEP IEP: Inferred from expression pattern	22758933	RGD
involved in cellular response to potassium ion	IEP IEP: Inferred from expression pattern	17403136	RGD
involved in hydrogen peroxide biosynthetic process	IDA IDA: Inferred from direct assay	10640619	RGD
involved in hydrogen peroxide biosynthetic process	IMP IMP: Inferred from mutant phenotype	15880490	RGD
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	11961082	RGD
involved in positive regulation of catalytic activity	IDA IDA: Inferred from direct assay	17324120	RGD
involved in removal of superoxide radicals	IDA IDA: Inferred from direct assay	10640619	RGD
involved in removal of superoxide radicals	IMP IMP: Inferred from mutant phenotype	21757500	RGD
involved in response to amphetamine	IEP IEP: Inferred from expression pattern	18452277	RGD
involved in response to antipsychotic drug	IEP IEP: Inferred from expression pattern	12111809	RGD
involved in response to carbon monoxide	IEP IEP: Inferred from expression pattern	19580685	RGD
involved in response to copper ion	IEP IEP: Inferred from expression pattern	12514262	RGD
involved in response to copper ion	IMP IMP: Inferred from mutant phenotype	14747682	RGD
involved in response to nutrient levels	IDA IDA: Inferred from direct assay	12067840	RGD
involved in response to nutrient levels	IEP IEP: Inferred from expression pattern	21562236	RGD
involved in response to oxidative stress	IMP IMP: Inferred from mutant phenotype	17663478	RGD
involved in superoxide metabolic process	IDA IDA: Inferred from direct assay	10640619	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in dense core granule	IDA IDA: Inferred from direct assay	17403136	RGD
located in extracellular region	IDA IDA: Inferred from direct assay	22572742	RGD
located in lysosome	IDA IDA: Inferred from direct assay	7096343	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	10640619	RGD
located in peroxisome	IDA IDA: Inferred from direct assay	19686298	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	19686298	RGD
located in secretory granule	IDA IDA: Inferred from direct assay	22572742	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

superoxide dismutase [Cu-Zn]

superoxide dismutase 1, soluble

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-132580	Tofersen		96.53%	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-16074	ATN-224		≥98.0%	Phase 2

Pre-clinical Phase

Bioactive Molecules (17)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-115445	LCS-1		99.81%	Unkown
HY-W115718	Cuprizone		≥99.0%	Unkown
HY-132580A	Tofersen sodium		97.19%	Unkown
HY-153019	NUCC-0000323	Inhibitor	99.85%	Unkown
HY-138131	SOD1-Derlin-1 inhibitor-1	Inhibitor	99.93%	Unkown
HY-123982	SOD1-Derlin-1 inhibitor-2	Inhibitor	99.86%	Unkown
HY-148901	CMB-087229	Inhibitor	98.05%	Unkown
HY-RS13559	SOD1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-145294	ROCK2-IN-5	Inhibitor	/	Unkown
HY-163772	Fraxinellone analog 1	Activator	/	Unkown
HY-169904	AKV-9	Inhibitor	99.98%	Unkown
HY-172152	MP-010		/	Unkown
HY-173025	Nurr1 agonist 12	Agonist	/	Unkown
HY-E70377	Cu/Zn Superoxide dismutase		/	Unkown
HY-P10627	SOD1 (147-153) human		/	Unkown
HY-RS16926	Sod1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23369	Sod1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sod1	NCBI	NCBI:6647

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