Sdc4 - syndecan 4 Gene

Rattus norvegicus

Also known as RYUDOCA; RATRYUDOCA

Gene ID: 24771 | Gene type: protein coding

About Sdc4

Summary

Enables fibronectin binding activity; identical protein binding activity; and protein kinase C binding activity. Involved in positive regulation of cellular component biogenesis; positive regulation of protein kinase activity; and ureteric bud development. Located in several cellular components, including costamere; focal adhesion; and membrane raft. Used to study Bacterial infectious disease. Orthologous to human SDC4 (syndecan 4). [provided by Alliance of Genome Resources, Apr 2022]

Sdc4 Products(1)

mRNA	Protein	Name
NM_012649.3	NP_036781.1	syndecan-4 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables fibronectin binding	IDA IDA: Inferred from direct assay	11372670	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	12571249	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	10640397	RGD
enables protein kinase C binding	IDA IDA: Inferred from direct assay	12571249	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of focal adhesion assembly	IMP IMP: Inferred from mutant phenotype	10504291	RGD
involved in positive regulation of protein kinase activity	IMP IMP: Inferred from mutant phenotype	12571249	RGD
involved in positive regulation of stress fiber assembly	IMP IMP: Inferred from mutant phenotype	10504291	RGD
NOT involved in regulation of aortic smooth muscle cell differentiation	IDA IDA: Inferred from direct assay	25089138	RGD
involved in ureteric bud development	IEP IEP: Inferred from expression pattern	15282150	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	10504291	RGD
located in costamere	IDA IDA: Inferred from direct assay	12209563	RGD
located in focal adhesion	IDA IDA: Inferred from direct assay	12493766	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

syndecan-4

Ryudocan/syndecan 4	SYND4
ryudocan core protein

Sdc4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Sdc4	P34901	Sdc2	Rattus norvegicus	P34900	Far-WB	26601939
Intra	Sdc4	P34901	Sdc2	Rattus norvegicus	P34900	Comigration in SDS	26601939
Intra	Sdc4	P34901	Sdcbp	Mus musculus	O08992	Y2H Pooling	10911369
Intra	Sdc4	P34901	Prkca	Rattus norvegicus	P05696	Anti Bait CoIP	12571249
Intra	Sdc4	P34901	PRKCA	Homo sapiens	P17252	Anti Bait CoIP	12571249
Intra	Sdc4	P34901	Sdc4	Rattus norvegicus	P34901	Y2H	12571249
Intra	Sdc4	P34901	Fn1	Rattus norvegicus	P04937	Comigration in Gel	10640397
Intra	Sdc4	P34901	Gipc1	Mus musculus	Q9Z0G0	Y2H Pooling	10911369
Intra	Sdc4	P34901	Sdc4	Rattus norvegicus	P34901	Comigration in SDS	26601939

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-159147	SIAIS039		99.68%	Unkown
HY-RS17074	Sdc4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS12582	SDC4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23518	Sdc4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sdc4	NCBI	NCBI:6385
Mus musculus	Sdc4	NCBI	NCBI:20971

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