Reln - reelin Gene

Rattus norvegicus

Also known as Rl; Reelen; reeler

Gene ID: 24718 | Gene type: protein coding

About Reln

Summary

Predicted to enable very-low-density lipoprotein particle receptor binding activity. Involved in several processes, including nervous system development; response to lithium ion; and response to steroid hormone. Located in several cellular components, including axon; dendrite; and perikaryon. Biomarker of hypothyroidism and status epilepticus. Human ortholog(s) of this gene implicated in Norman-Roberts syndrome; autistic disorder; familial temporal lobe epilepsy 7; and schizophrenia. Orthologous to human RELN (reelin). [provided by Alliance of Genome Resources, Apr 2022]

Reln Products(1)

mRNA	Protein	Name
NM_080394.3	NP_536319.3	reelin precursor

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to dexamethasone stimulus	IEP IEP: Inferred from expression pattern	11983443	RGD
involved in cerebral cortex development	IEP IEP: Inferred from expression pattern	10436054	RGD
involved in dentate gyrus development	IMP IMP: Inferred from mutant phenotype	15459104	RGD
involved in hypothalamus development	IEP IEP: Inferred from expression pattern	10436054	RGD
involved in locomotory behavior	IMP IMP: Inferred from mutant phenotype	12670697	RGD
involved in memory	IEP IEP: Inferred from expression pattern	17359920	RGD
involved in midgut development	IEP IEP: Inferred from expression pattern	19946030	RGD
involved in neuron migration	IMP IMP: Inferred from mutant phenotype	12670697	RGD
involved in orbitofrontal cortex development	IEP IEP: Inferred from expression pattern	20035841	RGD
involved in response to amino acid	IEP IEP: Inferred from expression pattern	16484373	RGD
involved in response to axon injury	IEP IEP: Inferred from expression pattern	18625290	RGD
involved in response to corticosterone	IEP IEP: Inferred from expression pattern	19477232	RGD
involved in response to electrical stimulus	IEP IEP: Inferred from expression pattern	19499587	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	15166098	RGD
involved in response to fatty acid	IEP IEP: Inferred from expression pattern	19447164	RGD
involved in response to hormone	IEP IEP: Inferred from expression pattern	20018181	RGD
involved in response to insecticide	IEP IEP: Inferred from expression pattern	16675515	RGD
involved in response to mechanical stimulus	IEP IEP: Inferred from expression pattern	19357777	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	17359920	RGD
involved in response to progesterone	IEP IEP: Inferred from expression pattern	18625290	RGD
involved in response to toxic substance	IEP IEP: Inferred from expression pattern	16733048	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	19359144	RGD
involved in social behavior	IEP IEP: Inferred from expression pattern	20035841	RGD
involved in spinal cord patterning	IEP IEP: Inferred from expression pattern	14648677	RGD
involved in synaptic vesicle exocytosis	EXP EXP: Inferred from Experiment	24210904	RGD
involved in synaptic vesicle exocytosis	IDA IDA: Inferred from direct assay	24210904	RGD
involved in synaptic vesicle exocytosis	IMP IMP: Inferred from mutant phenotype	24210904	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	16420448	RGD
located in dendrite	IDA IDA: Inferred from direct assay	19515914	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	18449964	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	19515914	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	11923015	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

reelin

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11835	RELN Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18151	Reln Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24626	Reln Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Reln	NCBI	NCBI:5649

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