Ptgs1 - prostaglandin-endoperoxide synthase 1 Gene

Rattus norvegicus

Also known as Cox1; Cox3; Cox-1; Cox-3; Pghs-1

Gene ID: 24693 | Gene type: protein coding

About Ptgs1

Summary

This is one of two genes encoding similar Enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. [provided by RefSeq, Jan 2014]

Ptgs1 Products(1)

mRNA	Protein	Name
NM_017043.4	NP_058739.4	prostaglandin G/H synthase 1 precursor

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in learning	IMP IMP: Inferred from mutant phenotype	21701788	RGD
involved in maintenance of blood-brain barrier	IMP IMP: Inferred from mutant phenotype	17704356	RGD
involved in memory	IMP IMP: Inferred from mutant phenotype	21701788	RGD
involved in negative regulation of epinephrine secretion	IMP IMP: Inferred from mutant phenotype	18598693	RGD
involved in negative regulation of norepinephrine secretion	IMP IMP: Inferred from mutant phenotype	18598693	RGD
involved in positive regulation of smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	18480553	RGD
involved in positive regulation of vasoconstriction	IMP IMP: Inferred from mutant phenotype	17245358	RGD
involved in prostaglandin biosynthetic process	IMP IMP: Inferred from mutant phenotype	17673564	RGD
involved in response to corticosterone	IEP IEP: Inferred from expression pattern	18584335	RGD
involved in response to fatty acid	IEP IEP: Inferred from expression pattern	16983392	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in nuclear envelope	IDA IDA: Inferred from direct assay	12657565	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

prostaglandin G/H synthase 1

PGH synthase 1	PHS 1
cyclooxygenase 3	cyclooxygenase-1
prostaglandin G/H synthase and cyclooxygenase	prostaglandin H2 synthase 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11392	PTGS1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19231	Ptgs1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25720	Ptgs1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ptgs1	NCBI	NCBI:5742

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