Prnp - prion protein Gene

Rattus norvegicus

Also known as PrP; Prn

Gene ID: 24686 | Gene type: protein coding

About Prnp

Summary

Enables several functions, including ATP-dependent protein binding activity; chaperone binding activity; and lamin binding activity. Involved in several processes, including negative regulation of long-term synaptic potentiation; positive regulation of protein localization to plasma membrane; and response to copper ion. Located in cytoplasm; plasma membrane; and postsynaptic density. Used to study hyperglycemia and scrapie. Human ortholog(s) of this gene implicated in Creutzfeldt-Jakob disease; Gerstmann-Straussler-Scheinker syndrome; Huntington's disease-like 1; fatal familial insomnia; and kuru. Orthologous to human PRNP (Prion Protein). [provided by Alliance of Genome Resources, Apr 2022]

Prnp Products(2)

mRNA	Protein	Name
NM_001395658.1	NP_001382587.1	major prion protein precursor
NM_012631.3	NP_036763.1	major prion protein precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP-dependent protein binding	IPI IPI: Inferred from physical interaction	16774738	RGD
enables lamin binding	IPI IPI: Inferred from physical interaction	21277044	RGD
enables protein-folding chaperone binding	IPI IPI: Inferred from physical interaction	16774738	RGD
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	16750514	RGD
enables type 5 metabotropic glutamate receptor binding	IPI IPI: Inferred from physical interaction	24012003	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in learning or memory	IMP IMP: Inferred from mutant phenotype	17156386	RGD
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	16766127	RGD
involved in negative regulation of catalytic activity	IDA IDA: Inferred from direct assay	23386614	RGD
involved in negative regulation of long-term synaptic potentiation	IDA IDA: Inferred from direct assay	21593310	RGD
involved in positive regulation of protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	23386614	RGD
involved in response to cadmium ion	IDA IDA: Inferred from direct assay	16148034	RGD
involved in response to copper ion	IDA IDA: Inferred from direct assay	16148034	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in postsynaptic density	IDA IDA: Inferred from direct assay	22820466	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

major prion protein

prion protein, PrP

prion protein, structural

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-176305S	Neurofilament, U-15N		/	Unkown
HY-RS11188	PRNP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18367	Prnp Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24846	Prnp Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Prnp	NCBI	NCBI:5621
Mus musculus	Prnp	NCBI	NCBI:19122

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