Klhl17 - kelch-like family member 17 Gene

Rattus norvegicus

Gene ID: 246757 | Gene type: protein coding

About Klhl17

Summary

Enables POZ domain binding activity; actin filament binding activity; and molecular adaptor activity. Involved in actin Cytoskeleton organization and brain development. Located in several cellular components, including dendrite cytoplasm; neuronal cell body; and postsynaptic density. Orthologous to human KLHL17 (kelch like family member 17). [provided by Alliance of Genome Resources, Apr 2022]

Klhl17 Products(1)

mRNA	Protein	Name
NM_145671.2	NP_663704.1	kelch-like protein 17

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables POZ domain binding	IPI IPI: Inferred from physical interaction	12063253	RGD
enables actin filament binding	IDA IDA: Inferred from direct assay	12063253	RGD
enables molecular adaptor activity	IDA IDA: Inferred from direct assay	17062563	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	16054660	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in actin cytoskeleton organization	IDA IDA: Inferred from direct assay	16054660	RGD
involved in regulation protein catabolic process at postsynapse	IDA IDA: Inferred from direct assay	17062563	RGD
involved in regulation protein catabolic process at postsynapse	IMP IMP: Inferred from mutant phenotype	17062563	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in actin cytoskeleton	IDA IDA: Inferred from direct assay	16054660	RGD
located in dendrite cytoplasm	IDA IDA: Inferred from direct assay	12063253	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	12063253	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	17062563	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	12063253	RGD
is active in postsynapse	IDA IDA: Inferred from direct assay	12063253	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

kelch-like protein 17

actinfilin

kelch-like 17

Klhl17 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Klhl17	Q8K430	Synpo	Mus musculus	Q8CC35-3	IF	37651441
Cross	Klhl17	Q8K430	Synpo	Mus musculus	Q8CC35-3	Anti Tag CoIP	37651441
Intra	Klhl17	Q8K430	Dlg4	Rattus norvegicus	P31016	Anti Bait CoIP	16054660
Intra	Klhl17	Q8K430	Pdzk1	Rattus norvegicus	Q9JJ40	Anti Tag CoIP	16054660
Intra	Klhl17	Q8K430	Pdzk1	Rattus norvegicus	Q9JJ40	Y2H	16054660
Intra	Klhl17	Q8K430	Pdzk1	Rattus norvegicus	Q9JJ40	Anti Bait CoIP	16054660

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07360	KLHL17 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Klhl17	NCBI	NCBI:339451

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