Pnmt - phenylethanolamine-N-methyltransferase Gene

Rattus norvegicus

Gene ID: 24661 | Gene type: protein coding

About Pnmt

Summary

Enables phenylethanolamine N-methyltransferase activity. Involved in several processes, including Catecholamine metabolic process; cellular response to dexamethasone stimulus; and response to peptide hormone. Located in several cellular components, including axon; dendrite; and perikaryon. Biomarker of hypertension and hypoglycemia. Human ortholog(s) of this gene implicated in Alzheimer's disease; hypertension; and multiple sclerosis. Orthologous to human PNMT (phenylethanolamine N-methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

Pnmt Products(1)

mRNA	Protein	Name
NM_031526.1	NP_113714.1	phenylethanolamine N-methyltransferase

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables phenylethanolamine N-methyltransferase activity	IDA IDA: Inferred from direct assay	683413	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in adrenal gland development	IEP IEP: Inferred from expression pattern	16140489	RGD
involved in cellular response to dexamethasone stimulus	IEP IEP: Inferred from expression pattern	15564339	RGD
involved in cellular response to growth factor stimulus	IEP IEP: Inferred from expression pattern	16926281	RGD
involved in cellular response to peptide hormone stimulus	IEP IEP: Inferred from expression pattern	16926281	RGD
involved in epinephrine biosynthetic process	IDA IDA: Inferred from direct assay	7914070	RGD
involved in norepinephrine metabolic process	IDA IDA: Inferred from direct assay	3945626	RGD
involved in response to activity	IEP IEP: Inferred from expression pattern	19120122	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	21382450	RGD
involved in response to ether	IEP IEP: Inferred from expression pattern	19120141	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	21046459	RGD
involved in response to immobilization stress	IEP IEP: Inferred from expression pattern	17683801	RGD
involved in response to insulin	IEP IEP: Inferred from expression pattern	15677399	RGD
involved in response to isolation stress	IEP IEP: Inferred from expression pattern	20203532	RGD
involved in response to peptide hormone	IEP IEP: Inferred from expression pattern	15380299	RGD
involved in social behavior	IEP IEP: Inferred from expression pattern	15345906	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	19651110	RGD
located in dendrite	IDA IDA: Inferred from direct assay	20434498	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	15869485	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	20434498	RGD
located in terminal bouton	IDA IDA: Inferred from direct assay	19651110	RGD
located in varicosity	IDA IDA: Inferred from direct assay	19651110	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

phenylethanolamine N-methyltransferase

PNMTase

noradrenaline N-methyltransferase

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-107398	1-(2,3-Dichlorophenyl)ethanamine hydrochloride	Inhibitor	99.93%	Unkown
HY-113969	7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline		/	Unkown
HY-149389	PNMT-IN-1	Inhibitor	/	Unkown
HY-RS10785	PNMT Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20796	Pnmt Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS27310	Pnmt Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pnmt	NCBI	NCBI:5409
Canis lupus familiaris	Pnmt	NCBI

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