Nexn - nexilin (F actin binding protein) Gene

Rattus norvegicus

Gene ID: 246172 | Gene type: protein coding

About Nexn

Summary

Enables actin filament binding activity. Predicted to be involved in several processes, including homophilic cell adhesion via plasma membrane adhesion molecules; neuron development; and regulation of Cytoskeleton organization. Predicted to act upstream of or within response to bacterium. Located in Z disc and focal adhesion. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1CC and hypertrophic cardiomyopathy 20. Orthologous to human NEXN (nexilin F-actin binding protein). [provided by Alliance of Genome Resources, Apr 2022]

Nexn Products(2)

mRNA	Protein	Name
NM_139230.2	NP_631976.1	nexilin isoform b
NM_139231.2	NP_631977.1	nexilin isoform s

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables actin filament binding	IDA IDA: Inferred from direct assay	9832551	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in Z disc	IDA IDA: Inferred from direct assay	19881492	RGD
located in cell-substrate junction	IDA IDA: Inferred from direct assay	9832551	RGD
located in focal adhesion	IDA IDA: Inferred from direct assay	9832551	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

nexilin

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09232	NEXN Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22253	Nexn Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28775	Nexn Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nexn	NCBI	NCBI:91624

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