Nppa - natriuretic peptide A Gene

Rattus norvegicus

Also known as ANF; ANP; CDD; Pnd; RATANF

Gene ID: 24602 | Gene type: protein coding

About Nppa

Summary

Enables hormone activity. Involved in several processes, including cGMP biosynthetic process; cellular response to mechanical stimulus; and regulation of ion transport. Acts upstream of or within receptor guanylyl cyclase signaling pathway. Located in several cellular components, including brush border; mast cell granule; and perinuclear region of cytoplasm. Used to study congestive heart failure; pulmonary hypertension; and ureteral obstruction. Biomarker of acute kidney failure; artery disease (multiple); hypertrophic cardiomyopathy; and nephrosis. Human ortholog(s) of this gene implicated in artery disease (multiple); heart conduction disease (multiple); and peritonitis. Orthologous to human NPPA (natriuretic peptide A). [provided by Alliance of Genome Resources, Apr 2022]

Nppa Products(1)

mRNA	Protein	Name
NM_012612.2	NP_036744.1	natriuretic peptides A precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables hormone activity	IDA IDA: Inferred from direct assay	7552344	RGD
enables signaling receptor binding	IDA IDA: Inferred from direct assay	11751587	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cGMP biosynthetic process	IMP IMP: Inferred from mutant phenotype	10559136	RGD
involved in cGMP-mediated signaling	IDA IDA: Inferred from direct assay	12217425	RGD
involved in cell growth involved in cardiac muscle cell development	IEP IEP: Inferred from expression pattern	7657802	RGD
involved in cellular response to angiotensin	IEP IEP: Inferred from expression pattern	27249171	RGD
involved in cellular response to hydrogen peroxide	IEP IEP: Inferred from expression pattern	27249171	RGD
involved in cellular response to mechanical stimulus	IEP IEP: Inferred from expression pattern	23617620	RGD
involved in negative regulation of cell growth	IMP IMP: Inferred from mutant phenotype	16010968	RGD
involved in negative regulation of collecting lymphatic vessel constriction	IDA IDA: Inferred from direct assay	23897233	RGD
involved in negative regulation of systemic arterial blood pressure	IDA IDA: Inferred from direct assay	2136863	RGD
involved in positive regulation of cGMP-mediated signaling	IDA IDA: Inferred from direct assay	7552344	RGD
involved in positive regulation of delayed rectifier potassium channel activity	IDA IDA: Inferred from direct assay	8301666	RGD
involved in positive regulation of histamine secretion by mast cell	IDA IDA: Inferred from direct assay	9663691	RGD
involved in positive regulation of potassium ion export across plasma membrane	IDA IDA: Inferred from direct assay	8301666	RGD
acts upstream of or within receptor guanylyl cyclase signaling pathway	IDA IDA: Inferred from direct assay	17951249	RGD
involved in regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	IDA IDA: Inferred from direct assay	8301666	RGD
involved in regulation of high voltage-gated calcium channel activity	IDA IDA: Inferred from direct assay	8301666	RGD
involved in response to 3-methylcholanthrene	IEP IEP: Inferred from expression pattern	19889059	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	2136863	RGD
involved in response to insulin	IEP IEP: Inferred from expression pattern	16828931	RGD
involved in synaptic signaling via neuropeptide	EXP EXP: Inferred from Experiment	24060848	RGD
involved in synaptic signaling via neuropeptide	IDA IDA: Inferred from direct assay	24060848	RGD
involved in synaptic signaling via neuropeptide	IMP IMP: Inferred from mutant phenotype	24060848	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in brush border	IDA IDA: Inferred from direct assay	1372667	RGD
is active in glycinergic synapse	EXP EXP: Inferred from Experiment	24060848	RGD
is active in glycinergic synapse	IDA IDA: Inferred from direct assay	24060848	RGD
is active in glycinergic synapse	IMP IMP: Inferred from mutant phenotype	24060848	RGD
located in mast cell granule	IDA IDA: Inferred from direct assay	16246270	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	16270351	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

natriuretic peptides A

Natriuretic peptide precursor A (pronatriodilatin, also Anf, Pnd)	atrial natriuretic factor prohormone
atrial natriuretic peptide prohormone	atriopeptigen
cardiodilatin	natriuretic peptide precursor type A
preproANF	preproANP
preproCDD-ANF	prepro

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09494	NPPA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS19624	Nppa Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26119	Nppa Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nppa	NCBI	NCBI:4878
Canis familiaris	Nppa	NCBI	NCBI:608289
Macaca fascicularis	Nppa	NCBI	NCBI:102116318
Mus musculus	Nppa	NCBI	NCBI:230899

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