2. Gene
  3. Irf1 - interferon regulatory factor 1 Gene

Irf1 - interferon regulatory factor 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 24508 | Gene type: protein coding

About Irf1

Summary

Enables sequence-specific DNA binding activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to exogenous dsRNA; and response to peptide hormone. Located in nucleus. Used to study endometrial adenocarcinoma. Biomarker of allergic conjunctivitis; lung disease; respiratory syncytial virus infectious disease; and ureteral obstruction. Human ortholog(s) of this gene implicated in asthma; gastric adenocarcinoma; lung non-small cell carcinoma; and smallpox. Orthologous to human IRF1 (interferon regulatory factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Irf1 Products(1)

mRNA Protein Name
NM_012591.2 NP_036723.2 interferon regulatory factor 1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
11880315 RGD
Biological Process GO Annotation Evidence Reference Source
involved in canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
15141302 RGD
involved in cellular response to exogenous dsRNA IEP
IEP: Inferred from expression pattern
11694343 RGD
involved in cellular response to interferon-beta IEP
IEP: Inferred from expression pattern
21261980 RGD
involved in cellular response to peptide hormone stimulus IDA
IDA: Inferred from direct assay
11022129 RGD
involved in cellular response to retinoic acid IEP
IEP: Inferred from expression pattern
15721283 RGD
involved in cellular response to tumor necrosis factor IDA
IDA: Inferred from direct assay
16978650 RGD
involved in cellular response to type II interferon IEP
IEP: Inferred from expression pattern
21261980 RGD
involved in female pregnancy IEP
IEP: Inferred from expression pattern
17651018 RGD
involved in negative regulation of protein modification process IMP
IMP: Inferred from mutant phenotype
20980260 RGD
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
21261980 RGD
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
11742807 RGD
involved in response to growth hormone IDA
IDA: Inferred from direct assay
9492014 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

interferon regulatory factor 1

IRF-1

Related Agents

Pre-clinical Phase
Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-171006 IRF1-IN-1 Inhibitor 99.72% Unkown
HY-133897 (Rac)-Indoximod 99.18% Unkown
HY-108052 Delphinidin 3-glucoside chloride 99.89% Unkown
HY-Y0148 10-Hydroxydecanoic acid Inhibitor 98.77% Unkown
HY-171007 IRF1-IN-2 99.83% Unkown
HY-RS06902 IRF1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS16716 Irf1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23151 Irf1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Irf1 NCBI NCBI:3659