2. Gene
  3. Ifnb1 - interferon beta 1 Gene

Ifnb1 - interferon beta 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Ifnb; If1da1

Gene ID: 24481 | Gene type: protein coding

About Ifnb1

Summary

Predicted to enable chloramphenicol O-acetyltransferase activity; cytokine activity; and type I interferon receptor binding activity. Involved in macrophage activation involved in immune response. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in COVID-19. Orthologous to human IFNB1 (interferon beta 1). [provided by Alliance of Genome Resources, Apr 2022]

Ifnb1 Products(1)

mRNA Protein Name
NM_019127.2 NP_062000.1 interferon beta precursor
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to dsDNA IEP
IEP: Inferred from expression pattern
33115500 RGD
involved in cellular response to dsRNA IEP
IEP: Inferred from expression pattern
15661832 RGD
involved in cellular response to exogenous dsRNA IEP
IEP: Inferred from expression pattern
18223009 RGD
involved in cellular response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
18412159 RGD
involved in cellular response to virus IEP
IEP: Inferred from expression pattern
15661832 RGD
involved in endoplasmic reticulum unfolded protein response IEP
IEP: Inferred from expression pattern
18412159 RGD
involved in macrophage activation involved in immune response IDA
IDA: Inferred from direct assay
10496312 RGD
involved in negative regulation of blood-brain barrier permeability IDA
IDA: Inferred from direct assay
12973019 RGD
involved in negative regulation of cell adhesion molecule production IDA
IDA: Inferred from direct assay
12044977 RGD
involved in negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
9126338 RGD
involved in negative regulation of immunoglobulin production IDA
IDA: Inferred from direct assay
10494101 RGD
involved in negative regulation of matrix metallopeptidase secretion IDA
IDA: Inferred from direct assay
15222694 RGD
involved in negative regulation of mononuclear cell migration IDA
IDA: Inferred from direct assay
12044977 RGD
involved in negative regulation of neuroinflammatory response IDA
IDA: Inferred from direct assay
12973019 RGD
involved in negative regulation of type II interferon production IDA
IDA: Inferred from direct assay
10494101 RGD
involved in positive regulation of transforming growth factor beta production IDA
IDA: Inferred from direct assay
10494101 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

interferon beta

IFN-beta

interferon 1da1

interferon beta 1, fibroblast

Related Agents

Clinical Phase
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P990036 Dazukibart Inhibitor 99.76% Phase 3
Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-138682 STING-IN-2 Inhibitor 99.71% Unkown
HY-RS06585 IFNB1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS17301 Ifnb1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23756 Ifnb1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ifnb1 NCBI NCBI:3456
Mus musculus Ifnb1 NCBI NCBI:15977
Macaca mulatta Ifnb1 NCBI NCBI:711414