Hspa1a - heat shock protein family A (Hsp70) member 1A Gene

Rattus norvegicus

Also known as HSP72; Hspa1; Hspa1b; HSP70-2; HSP70.1; HSP70.2; Hsp70-1

Gene ID: 24472 | Gene type: protein coding

About Hspa1a

Summary

Predicted to enable several functions, including ATP binding activity; enzyme binding activity; and protein domain specific binding activity. Involved in several processes, including response to ethanol; response to ischemia; and response to unfolded protein. Located in membrane raft. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; autoimmune disease of musculoskeletal system (multiple); cystic fibrosis; schizophrenia (multiple); and toxic shock syndrome. Orthologous to several human genes including HSPA1B (heat shock protein family A (HSP70) member 1B). [provided by Alliance of Genome Resources, Apr 2022]

Hspa1a Products(1)

mRNA	Protein	Name
NM_031971.2	NP_114177.2	heat shock 70 kDa protein 1A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables NF-kappaB binding	IPI IPI: Inferred from physical interaction	16135962	RGD
enables protease binding	IPI IPI: Inferred from physical interaction	16397188	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	9553041	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in defense response	IDA IDA: Inferred from direct assay	11820796	RGD
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	16397188	RGD
involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: Inferred from direct assay	16397188	RGD
NOT involved in negative regulation of myeloid cell apoptotic process	IDA IDA: Inferred from direct assay	10679071	RGD
involved in negative regulation of vasoconstriction	IMP IMP: Inferred from mutant phenotype	15381648	RGD
involved in positive regulation of T cell mediated cytotoxicity	IDA IDA: Inferred from direct assay	10679071	RGD
involved in response to unfolded protein	IMP IMP: Inferred from mutant phenotype	8271311	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	16609151	RGD
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	16609151	RGD
located in membrane raft	IDA IDA: Inferred from direct assay	14499952	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	16135962	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

heat shock 70 kDa protein 1A

HSP70-1/HSP70-2	HSP70.1/2
HSP70.1/HSP70.2	Heat shock 70 kDa protein 1
heat shock 70 kDa protein 1/2	heat shock 70 kDa protein 1A/1B
heat shock 70 kDa protein 1B	heat shock 70 kDa protein 2
heat shock 70kD protein 1A	heat shock protein 70-1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06424	HSPA1A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18094	Hspa1a Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24569	Hspa1a Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hspa1a	NCBI	NCBI:3303

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