2. Gene
  3. Kdm4d - lysine (K)-specific demethylase 4D Gene

Kdm4d - lysine (K)-specific demethylase 4D Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Jmjd2d; 4932416A15

Gene ID: 244694 | Gene type: protein coding

About Kdm4d

Summary

Enables chromatin DNA binding activity; damaged DNA binding activity; and histone H3-methyl-lysine-9 demethylase activity. Acts upstream of or within cellular response to DNA damage stimulus; histone H3-K9 demethylation; and negative regulation of histone H3-K9 trimethylation. Located in nucleus; pericentric heterochromatin; and site of double-strand break. Orthologous to several human genes including KDM4D (lysine demethylase 4D). [provided by Alliance of Genome Resources, Apr 2022]

Kdm4d Products(2)

mRNA Protein Name
NM_001410506.1 NP_001397435.1 lysine-specific demethylase 4D
NM_173433.3 NP_775609.2 lysine-specific demethylase 4D
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables chromatin DNA binding IDA
IDA: Inferred from direct assay
6953429 MGI
enables damaged DNA binding IDA
IDA: Inferred from direct assay
24550317 MGI
enables histone H3K9 demethylase activity IDA
IDA: Inferred from direct assay
16738407 MGI
enables histone H3K9 demethylase activity IMP
IMP: Inferred from mutant phenotype
21293030 MGI
enables histone demethylase activity IDA
IDA: Inferred from direct assay
19144645 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within DNA damage response IDA
IDA: Inferred from direct assay
24550317 MGI
Cellular Component GO Annotation Evidence Reference Source
located in nucleus IDA
IDA: Inferred from direct assay
24550317 MGI
located in pericentric heterochromatin IDA
IDA: Inferred from direct assay
16738407 MGI
located in site of double-strand break IDA
IDA: Inferred from direct assay
24550317 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

lysine-specific demethylase 4D

[histone H3]-trimethyl-L-lysine(9) demethylase 4D

jmjC domain-containing histone demethylation protein 3D

jumonji domain containing 2D

jumonji domain-containing protein 2D

Related Agents

Pre-clinical Phase
Bioactive Molecules (10)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-104048 QC6352 Inhibitor 99.13% Unkown
HY-101928 KDM4D-IN-1 Inhibitor 98.82% Unkown
HY-148807 Zavondemstat Inhibitor 99.12% Unkown
HY-148807A Zavondemstat L-lysine Inhibitor / Unkown
HY-148807B (S)-Zavondemstat Control 97.51% Unkown
HY-173135 PROTAC KDM4 degrader-1 / Unkown
HY-RS07216 KDM4D Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-157408 KDM4D-IN-3 / Unkown
HY-RS20046 Kdm4d Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS26549 Kdm4d Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kdm4d NCBI NCBI:55693