Hmox1 - heme oxygenase 1 Gene

Rattus norvegicus

Also known as Ho1; Heox; Hmox; Ho-1; HEOXG; hsp32

Gene ID: 24451 | Gene type: protein coding

About Hmox1

Summary

Enables several functions, including heme binding activity; heme oxygenase (decyclizing) activity; and Phospholipase D activity. Involved in several processes, including intracellular signal transduction; negative regulation of apoptotic process; and regulation of gene expression. Located in several cellular components, including caveola; endoplasmic reticulum; and nucleolus. Used to study several diseases, including artery disease (multiple); cerebrovascular disease (multiple); hepatic vascular disease (multiple); limb ischemia; and sciatic neuropathy. Biomarker of several diseases, including Sjogren's syndrome; artery disease (multiple); brain disease (multiple); liver disease (multiple); and lung disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebrovascular disease (multiple); Factor VIII deficiency; lung disease (multiple); and type 2 diabetes mellitus. Orthologous to human HMOX1 (heme oxygenase 1). [provided by Alliance of Genome Resources, Apr 2022]

Hmox1 Products(1)

mRNA	Protein	Name
NM_012580.2	NP_036712.1	heme oxygenase 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables arachidonate omega-hydroxylase activity	IMP IMP: Inferred from mutant phenotype	19889059	RGD
enables enzyme binding	IPI IPI: Inferred from physical interaction	15516695	RGD
enables heme binding	IDA IDA: Inferred from direct assay	12044160	RGD
enables heme oxygenase (decyclizing) activity	IDA IDA: Inferred from direct assay	1575508	RGD
enables phospholipase D activity	IDA IDA: Inferred from direct assay	12511545	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	15226268	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in angiogenesis	IDA IDA: Inferred from direct assay	12593860	RGD
involved in cellular response to nutrient	IEP IEP: Inferred from expression pattern	15531134	RGD
involved in heme catabolic process	IDA IDA: Inferred from direct assay	15226268	RGD
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	12225959	RGD
involved in intrinsic apoptotic signaling pathway in response to DNA damage	IDA IDA: Inferred from direct assay	11854317	RGD
involved in liver regeneration	IMP IMP: Inferred from mutant phenotype	24815159	RGD
involved in negative regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	17234154	RGD
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	16319139	RGD
involved in negative regulation of epithelial cell apoptotic process	IMP IMP: Inferred from mutant phenotype	22093310	RGD
involved in negative regulation of mast cell cytokine production	IDA IDA: Inferred from direct assay	17234154	RGD
involved in negative regulation of mast cell degranulation	IDA IDA: Inferred from direct assay	17234154	RGD
involved in negative regulation of muscle cell apoptotic process	IDA IDA: Inferred from direct assay	12396617	RGD
involved in negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	19177228	RGD
involved in negative regulation of smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	19885007	RGD
involved in negative regulation of vascular associated smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	22709785	RGD
involved in positive regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	20925964	RGD
involved in regulation of blood pressure	IDA IDA: Inferred from direct assay	12215473	RGD
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17430897	RGD
involved in response to 3-methylcholanthrene	IEP IEP: Inferred from expression pattern	19889059	RGD
involved in response to arachidonate	IMP IMP: Inferred from mutant phenotype	19889059	RGD
involved in response to estrogen	IDA IDA: Inferred from direct assay	15734876	RGD
involved in response to hydrogen peroxide	IDA IDA: Inferred from direct assay	17430897	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	14970910	RGD
involved in response to hypoxia	IMP IMP: Inferred from mutant phenotype	12114196	RGD
involved in response to oxidative stress	IDA IDA: Inferred from direct assay	17020887	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	29091898	RGD
involved in small GTPase-mediated signal transduction	IDA IDA: Inferred from direct assay	12511545	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in caveola	IDA IDA: Inferred from direct assay	15226268	RGD
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	3865203	RGD
located in nucleus	IDA IDA: Inferred from direct assay	17430897	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

heme oxygenase 1

heme oxygenase (decycling) 1

heme oxygenase (decyclizing) 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0643	Carnosol		99.90%	Unkown
HY-124815	CP-312	Inducer	99.69%	Unkown
HY-RS06249	HMOX1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-147517	Keap1-Nrf2-IN-9	Inhibitor	98.52%	Unkown
HY-121523	MIND4-17	Activator	99.93%	Unkown
HY-149245	Keap1-Nrf2-IN-15	Inhibitor	/	Unkown
HY-170968	EGFR-IN-150	Inhibitor	/	Unkown
HY-173444	HDAC11-IN-3		/	Unkown
HY-RS16718	Hmox1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23153	Hmox1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hmox1	NCBI	NCBI:3162
Mus musculus	Hmox1	NCBI	NCBI:15368

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