Grin1 - glutamate ionotropic receptor NMDA type subunit 1 Gene

Rattus norvegicus

Also known as NR1; GluN1; NMDAR1

Gene ID: 24408 | Gene type: protein coding

About Grin1

Summary

Enables several functions, including amino acid binding activity; amyloid-beta binding activity; and ligand-gated ion channel activity. Involved in several processes, including positive regulation of dendritic spine maintenance; protein heterotetramerization; and response to fungicide. Located in several cellular components, including dendrite; postsynaptic density; and synaptic cleft. Is integral component of plasma membrane. Part of NMDA selective glutamate receptor complex. Is active in glutamatergic synapse; hippocampal mossy fiber to CA3 synapse; and parallel fiber to Purkinje cell synapse. Is integral component of postsynaptic density membrane and integral component of presynaptic membrane. Biomarker of cognitive disorder; middle cerebral artery infarction; placental insufficiency; sciatic neuropathy; and status epilepticus. Human ortholog(s) of this gene implicated in alcohol use disorder; autosomal dominant non-syndromic intellectual disability 8; and cerebral infarction. Orthologous to human GRIN1 (glutamate ionotropic receptor NMDA type subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

Grin1 Products(8)

mRNA	Protein	Name
NM_001270602.1	NP_001257531.1	glutamate receptor ionotropic, NMDA 1 isoform 1b precursor
NM_001270603.1	NP_001257532.1	glutamate receptor ionotropic, NMDA 1 isoform 2b precursor
NM_001270605.1	NP_001257534.1	glutamate receptor ionotropic, NMDA 1 isoform 2a precursor
NM_001270606.1	NP_001257535.1	glutamate receptor ionotropic, NMDA 1 isoform 3b precursor
NM_001270608.1	NP_001257537.1	glutamate receptor ionotropic, NMDA 1 isoform 4b precursor
NM_001270610.1	NP_001257539.1	glutamate receptor ionotropic, NMDA 1 isoform 4a precursor
NM_001287423.1	NP_001274352.1	glutamate receptor ionotropic, NMDA 1 isoform 3a precursor
NM_017010.2	NP_058706.1	glutamate receptor ionotropic, NMDA 1 isoform 1a precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables NMDA glutamate receptor activity	IDA IDA: Inferred from direct assay	1350383	RGD
enables NMDA glutamate receptor activity	IGI IGI: Inferred from genetic interaction	7929101	RGD
enables NMDA glutamate receptor activity	IMP IMP: Inferred from mutant phenotype	17050728	RGD
enables amyloid-beta binding	IDA IDA: Inferred from direct assay	17308309	RGD
enables enzyme binding	IPI IPI: Inferred from physical interaction	15069201	RGD
enables glutamate binding	IDA IDA: Inferred from direct assay	8011339	RGD
enables glutamate receptor binding	IPI IPI: Inferred from physical interaction	11239437	RGD
enables glutamate-gated receptor activity	IDA IDA: Inferred from direct assay	16477151	RGD
enables glycine binding	IDA IDA: Inferred from direct assay	8011339	RGD
enables ionotropic glutamate receptor binding	IPI IPI: Inferred from physical interaction	10414981	RGD
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	EXP EXP: Inferred from Experiment	19666514	RGD
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IDA IDA: Inferred from direct assay	19666514	RGD
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IMP IMP: Inferred from mutant phenotype	19666514	RGD
enables phosphatase binding	IDA IDA: Inferred from direct assay	15102920	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	8780649	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	21544205	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	17308309	RGD
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	12408866	RGD
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IDA IDA: Inferred from direct assay	12160751	RGD
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IMP IMP: Inferred from mutant phenotype	12160751	RGD
enables voltage-gated monoatomic cation channel activity	IMP IMP: Inferred from mutant phenotype	17050728	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in calcium ion transmembrane transport	IDA IDA: Inferred from direct assay	1350383	RGD
involved in cellular response to glycine	IEP IEP: Inferred from expression pattern	23678131	RGD
involved in cellular response to manganese ion	IEP IEP: Inferred from expression pattern	19643132	RGD
involved in ionotropic glutamate receptor signaling pathway	IDA IDA: Inferred from direct assay	16477151	RGD
involved in monoatomic cation transmembrane transport	IDA IDA: Inferred from direct assay	22246434	RGD
involved in positive regulation of Schwann cell migration	IMP IMP: Inferred from mutant phenotype	26656067	RGD
involved in positive regulation of calcium ion transport into cytosol	IGI IGI: Inferred from genetic interaction	17308309	RGD
involved in positive regulation of dendritic spine maintenance	IGI IGI: Inferred from genetic interaction	17360908	RGD
involved in positive regulation of excitatory postsynaptic potential	IDA IDA: Inferred from direct assay	12930820	RGD
involved in positive regulation of reactive oxygen species biosynthetic process	IGI IGI: Inferred from genetic interaction	17308309	RGD
involved in positive regulation of synaptic transmission, glutamatergic	IDA IDA: Inferred from direct assay	19793963	RGD
involved in protein heterotetramerization	IDA IDA: Inferred from direct assay	24876489	RGD
involved in protein-containing complex assembly	IDA IDA: Inferred from direct assay	22493736	RGD
involved in regulation of monoatomic cation transmembrane transport	IDA IDA: Inferred from direct assay	19793963	RGD
involved in response to amine	IEP IEP: Inferred from expression pattern	19918184	RGD
involved in response to calcium ion	IEP IEP: Inferred from expression pattern	19761817	RGD
involved in response to fungicide	IEP IEP: Inferred from expression pattern	19591855	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	18927268	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	19322657	RGD
involved in rhythmic process	IDA IDA: Inferred from direct assay	16477151	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of NMDA selective glutamate receptor complex	IDA IDA: Inferred from direct assay	16477151	RGD
located in cell surface	IDA IDA: Inferred from direct assay	17526495	RGD
located in cytoplasm	IDA IDA: Inferred from direct assay	16477151	RGD
located in dendrite membrane	IDA IDA: Inferred from direct assay	15620359	RGD
located in dendritic branch	IDA IDA: Inferred from direct assay	10618500	RGD
located in dendritic spine	IDA IDA: Inferred from direct assay	17207780	RGD
located in excitatory synapse	IDA IDA: Inferred from direct assay	19730411	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	12160751	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	12160751	RGD
is active in hippocampal mossy fiber to CA3 synapse	IDA IDA: Inferred from direct assay	23159309	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	10618500	RGD
is active in parallel fiber to Purkinje cell synapse	IDA IDA: Inferred from direct assay	19666514	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	1350383	RGD
is active in postsynaptic density membrane	IDA IDA: Inferred from direct assay	23159309	RGD
located in postsynaptic density membrane	IDA IDA: Inferred from direct assay	26041915	RGD
is active in presynaptic active zone membrane	IDA IDA: Inferred from direct assay	23159309	RGD
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	19666514	RGD
located in synapse	IDA IDA: Inferred from direct assay	15681343	RGD
located in synaptic cleft	IDA IDA: Inferred from direct assay	17207780	RGD
located in synaptic membrane	IDA IDA: Inferred from direct assay	10414981	RGD
located in synaptic membrane	IPI IPI: Inferred from physical interaction	17308309	RGD
located in terminal bouton	IDA IDA: Inferred from direct assay	19666514	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

glutamate receptor ionotropic, NMDA 1

N-methyl-D-aspartate glutamate receptor	N-methyl-D-aspartate receptor subunit NR1
NMD-R1	NMDA R1 receptor C1 cassette
glutamate [NMDA] receptor subunit zeta-1	glutamate receptor, ionotropic, N-methyl D-aspartate 1
neurotransmitter receptor

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05754	GPRIN1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS05803	GRIN1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20948	Grin1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS27465	Grin1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Grin1	NCBI	NCBI:2902

Name
Email *

	Sorry, but the email address you supplied was invalid.