Got1 - glutamic-oxaloacetic transaminase 1 Gene

Rattus norvegicus

Also known as AAT1; ASAT; cCAT; Aspat; Gaspat; cAspAT

Gene ID: 24401 | Gene type: protein coding

About Got1

Summary

Enables L-aspartate:2-oxoglutarate aminotransferase activity; L-cysteine:2-oxoglutarate aminotransferase activity; and carboxylic acid binding activity. Involved in several processes, including cellular response to mechanical stimulus; dicarboxylic acid metabolic process; and ion homeostasis. Located in axon terminus; cytosol; and lysosome. Used to study transient cerebral ischemia. Biomarker of cardiomyopathy. Human ortholog(s) of this gene implicated in amyloidosis; amyotrophic lateral sclerosis; pancreatic ductal adenocarcinoma; and transient cerebral ischemia. Orthologous to human GOT1 (glutamic-oxaloacetic transaminase 1). [provided by Alliance of Genome Resources, Apr 2022]

Got1 Products(1)

mRNA	Protein	Name
NM_012571.2	NP_036703.2	aspartate aminotransferase, cytoplasmic

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables L-aspartate:2-oxoglutarate aminotransferase activity	IDA IDA: Inferred from direct assay	2837211	RGD
enables L-aspartate:2-oxoglutarate aminotransferase activity	IMP IMP: Inferred from mutant phenotype	7562489	RGD
enables L-cysteine transaminase activity	IDA IDA: Inferred from direct assay	7113743	RGD
enables carboxylic acid binding	IDA IDA: Inferred from direct assay	2837211	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in L-glutamate biosynthetic process	IDA IDA: Inferred from direct assay	16489927	RGD
involved in aspartate metabolic process	IDA IDA: Inferred from direct assay	2837211	RGD
involved in cellular response to mechanical stimulus	IDA IDA: Inferred from direct assay	26880260	RGD
involved in dicarboxylic acid metabolic process	IDA IDA: Inferred from direct assay	2837211	RGD
involved in dicarboxylic acid metabolic process	IMP IMP: Inferred from mutant phenotype	7562489	RGD
involved in glycerol biosynthetic process	IDA IDA: Inferred from direct assay	17545671	RGD
involved in negative regulation of collagen biosynthetic process	IMP IMP: Inferred from mutant phenotype	26880260	RGD
involved in negative regulation of cytosolic calcium ion concentration	IMP IMP: Inferred from mutant phenotype	29215467	RGD
involved in negative regulation of mitochondrial depolarization	IMP IMP: Inferred from mutant phenotype	29215467	RGD
involved in oxaloacetate metabolic process	IDA IDA: Inferred from direct assay	16489927	RGD
involved in positive regulation of transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	26880260	RGD
involved in response to cadmium ion	IEP IEP: Inferred from expression pattern	29101047	RGD
involved in response to carbohydrate	IEP IEP: Inferred from expression pattern	29101047	RGD
involved in response to immobilization stress	IEP IEP: Inferred from expression pattern	25451275	RGD
involved in response to transition metal nanoparticle	IDA IDA: Inferred from direct assay	28962237	RGD
involved in transdifferentiation	IMP IMP: Inferred from mutant phenotype	28797105	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon terminus	IDA IDA: Inferred from direct assay	2364283	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

aspartate aminotransferase, cytoplasmic

aspartate aminotransferase 1	cysteine aminotransferase, cytoplasmic
cysteine transaminase, cytoplasmic	cytosolic aspartate aminotransferase
glutamate oxaloacetate transaminase 1, soluble	glutamic-oxaloacetic transaminase 1, soluble
transaminase A

Related Agents

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-B0091	Adapalene	99.98%	Yes
HY-B0091R	Adapalene (Standard)	/	Unkown
HY-B0091A	Adapalene sodium salt	/	Unkown

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-122723	GOT1 inhibitor-1	Inhibitor	99.45%	Unkown
HY-160818	MC3138	Activator	99.27%	Unkown
HY-124825	iGOT1-01		99.77%	Unkown
HY-N3307	(+)-Medioresinol		98.88%	Unkown
HY-N6237	Aspulvinone O		≥96.0%	Unkown
HY-RS05605	GOT1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-B0091S	Adapalene-d3		/	Unkown
HY-RS05596	GOLT1A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16967	Got1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23410	Got1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Got1	NCBI	NCBI:2805

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