G6pd - glucose-6-phosphate dehydrogenase Gene

Rattus norvegicus

Also known as G6pdx

Gene ID: 24377 | Gene type: protein coding

About G6pd

Summary

Enables NADP binding activity; glucose binding activity; and glucose-6-phosphate dehydrogenase activity. Involved in several processes, including negative regulation of cell growth involved in cardiac muscle cell development; pentose-phosphate shunt, oxidative branch; and positive regulation of calcium ion transmembrane transport via high voltage-gated Calcium Channel. Located in cytosol and nucleus. Used to study cataract and transient cerebral ischemia. Biomarker of several diseases, including artery disease (multiple); hepatic encephalopathy; hyperhomocysteinemia; obesity; and phenylketonuria. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); cerebrovascular disease; favism; malaria (multiple); and neonatal jaundice. Orthologous to human G6PD (glucose-6-phosphate dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]

G6pd Products(1)

mRNA	Protein	Name
NM_017006.2	NP_058702.1	glucose-6-phosphate 1-dehydrogenase

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables D-glucose binding	IDA IDA: Inferred from direct assay	17447164	RGD
enables D-glucose binding	IMP IMP: Inferred from mutant phenotype	16325866	RGD
enables NADP binding	IDA IDA: Inferred from direct assay	17447164	RGD
enables NADP binding	IMP IMP: Inferred from mutant phenotype	16325866	RGD
enables carbohydrate binding	IDA IDA: Inferred from direct assay	2843500	RGD
enables glucose-6-phosphate dehydrogenase activity	IDA IDA: Inferred from direct assay	1834654	RGD
enables glucose-6-phosphate dehydrogenase activity	IMP IMP: Inferred from mutant phenotype	16325866	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in glucose 6-phosphate metabolic process	IDA IDA: Inferred from direct assay	17447164	RGD
involved in glucose 6-phosphate metabolic process	IMP IMP: Inferred from mutant phenotype	16325866	RGD
involved in negative regulation of cell growth involved in cardiac muscle cell development	IMP IMP: Inferred from mutant phenotype	24190878	RGD
involved in negative regulation of reactive oxygen species metabolic process	IMP IMP: Inferred from mutant phenotype	24190878	RGD
involved in pentose-phosphate shunt	IDA IDA: Inferred from direct assay	2843500	RGD
involved in pentose-phosphate shunt, oxidative branch	IMP IMP: Inferred from mutant phenotype	9794092	RGD
involved in positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	IMP IMP: Inferred from mutant phenotype	23071515	RGD
involved in regulation of neuron apoptotic process	IDA IDA: Inferred from direct assay	12414804	RGD
involved in response to ethanol	IDA IDA: Inferred from direct assay	18488910	RGD
involved in response to food	IEP IEP: Inferred from expression pattern	19076169	RGD
involved in response to iron(III) ion	IEP IEP: Inferred from expression pattern	24599681	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	17250641	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

glucose-6-phosphate 1-dehydrogenase

glucose-6-phosphate dehydrogenase X-linked

Related Agents

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-16438	RRx-001		99.79%	Phase 3
HY-125863	Glucose-6-phosphate dehydrogenase, Microorganism		/	Phase 3
HY-N0120A	Polydatin		99.47%	Phase 2
HY-106328	Fluasterone	Inhibitor	99.85%	Phase 2

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W010342	6-Aminonicotinamide		99.95%	Unkown
HY-W107464	G6PDi-1		99.81%	Unkown
HY-123962	G6PD activator AG1		99.54%	Unkown
HY-N0120AR	Polydatin (Standard)		98.28%	Unkown
HY-RS05194	G6PD Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-125863A	Glucose-6-phosphate dehydrogenase (Leuconostoc sp., recombinant)		/	Unkown
HY-125863B	Glucose 6-phosphate dehydrogenase (yeast, recombinant)		/	Unkown
HY-125863C	Glucose-6-phosphate dehydrogenase, Bacillus sp.		/	Unkown
HY-RS22997	G6pd Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	G6pd	NCBI	NCBI:2539

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