Epor - erythropoietin receptor Gene

Rattus norvegicus

Gene ID: 24336 | Gene type: protein coding

About Epor

Summary

Enables erythropoietin receptor activity. Involved in several processes, including cellular response to kainic acid; negative regulation of cell death; and negative regulation of nitric oxide biosynthetic process. Located in cytoplasm and external side of plasma membrane. Used to study high grade glioma. Biomarker of several diseases, including brain ischemia; cholangiocarcinoma; end stage renal disease; eye disease (multiple); and hepatic encephalopathy. Human ortholog(s) of this gene implicated in anemia; familial erythrocytosis 1; high grade glioma; polycythemia; and systemic lupus erythematosus. Orthologous to human EPOR (erythropoietin receptor). [provided by Alliance of Genome Resources, Apr 2022]

Epor Products(1)

mRNA	Protein	Name
NM_017002.2	NP_058698.2	erythropoietin receptor precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables erythropoietin receptor activity	IDA IDA: Inferred from direct assay	7684373	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to kainic acid	IEP IEP: Inferred from expression pattern	18711747	RGD
involved in negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	12451129	RGD
involved in negative regulation of nitric oxide biosynthetic process	IMP IMP: Inferred from mutant phenotype	10489101	RGD
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	21749867	RGD
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	21749867	RGD
involved in positive regulation of cytosolic calcium ion concentration	IDA IDA: Inferred from direct assay	7684373	RGD
involved in positive regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	22469063	RGD
involved in positive regulation of response to reactive oxygen species	IMP IMP: Inferred from mutant phenotype	23636173	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	21624288	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	27587253	RGD
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	21649646	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

erythropoietin receptor

EPO-R

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-18960	CHZ868	Inhibitor	99.56%	Unkown
HY-W062700	STS-E412	Activator	99.72%	Unkown
HY-RS04448	EPOR Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18356	Epor Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24835	Epor Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Epor	NCBI	NCBI:2057
Macaca fascicularis	Epor	NCBI	NCBI:102138718
Mus musculus	Epor	NCBI	NCBI:13857
Macaca mulatta	Epor	NCBI	NCBI:714546

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