Nqo1 - NAD(P)H quinone dehydrogenase 1 Gene

Rattus norvegicus

Also known as Dia4

Gene ID: 24314 | Gene type: protein coding

About Nqo1

Summary

Enables NAD(P)H dehydrogenase (quinone) activity and superoxide dismutase activity. Involved in several processes, including NADPH oxidation; regulation of apoptotic process; and response to ischemia. Located in cytosol; dendrite; and neuronal cell body. Used to study several diseases, including chronic kidney disease; colon cancer; hypertension; liver cirrhosis; and membranous glomerulonephritis. Biomarker of several diseases, including brain disease (multiple); chronic obstructive pulmonary disease; fatty liver disease (multiple); prostatitis; and ureteral obstruction. Human ortholog(s) of this gene implicated in several diseases, including asthma; hematologic Cancer (multiple); lung disease (multiple); macular degeneration; and small cell carcinoma. Orthologous to human NQO1 (NAD(P)H quinone dehydrogenase 1). [provided by Alliance of Genome Resources, Apr 2022]

Nqo1 Products(2)

mRNA	Protein	Name
NM_017000.3	NP_058696.2	NAD(P)H dehydrogenase [quinone] 1
NM_017000.3	NP_058696.2	NAD(P)H dehydrogenase [quinone] 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables NAD(P)H dehydrogenase (quinone) activity	IDA IDA: Inferred from direct assay	12603827	RGD
enables NADH:ubiquinone reductase (non-electrogenic) activity	IDA IDA: Inferred from direct assay	8999809	RGD
enables superoxide dismutase activity	IMP IMP: Inferred from mutant phenotype	17901563	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in NADH oxidation	IDA IDA: Inferred from direct assay	29389585	RGD
involved in NADPH oxidation	IDA IDA: Inferred from direct assay	29444417	RGD
involved in cellular response to hydrogen peroxide	IDA IDA: Inferred from direct assay	28271112	RGD
involved in cellular response to metal ion	IEP IEP: Inferred from expression pattern	28722058	RGD
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	22227174	RGD
involved in positive regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	12603827	RGD
involved in response to L-glutamine	IDA IDA: Inferred from direct assay	30967905	RGD
involved in response to alkaloid	IEP IEP: Inferred from expression pattern	31432116	RGD
involved in response to amine	IDA IDA: Inferred from direct assay	29444417	RGD
involved in response to carbohydrate	IEP IEP: Inferred from expression pattern	31933629	RGD
involved in response to electrical stimulus	IEP IEP: Inferred from expression pattern	28887183	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	14672740	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	20833713	RGD
involved in response to flavonoid	IEP IEP: Inferred from expression pattern	31399183	RGD
involved in response to hormone	IEP IEP: Inferred from expression pattern	30483575	RGD
involved in response to hydrogen sulfide	IEP IEP: Inferred from expression pattern	29054567	RGD
involved in response to ischemia	IEP IEP: Inferred from expression pattern	31399183	RGD
involved in response to nutrient	IEP IEP: Inferred from expression pattern	21092375	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	21549141	RGD
involved in response to oxidative stress	IEP IEP: Inferred from expression pattern	12011483	RGD
involved in response to testosterone	IEP IEP: Inferred from expression pattern	31819135	RGD
involved in response to tetrachloromethane	IEP IEP: Inferred from expression pattern	30483575	RGD
involved in response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	30967905	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	29091898	RGD
involved in superoxide metabolic process	IMP IMP: Inferred from mutant phenotype	17901563	RGD
involved in vitamin K metabolic process	IDA IDA: Inferred from direct assay	8999809	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in dendrite	IDA IDA: Inferred from direct assay	28322084	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	14991562	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

NAD(P)H dehydrogenase [quinone] 1

DT-diaphorase	DTD
Diaphorase (NADH/NADPH)	NAD(P)H dehydrogenase, quinone 1
NAD(P)H:menadione oxidoreductase	NAD(P)H:quinone oxidoreductase 1
QR1	azoreductase
menadione reductase	phylloquinone reductase
quinone reductase 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-170947	Antitumor agent-195	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nqo1	NCBI	NCBI:1728
Mus musculus	Nqo1	NCBI	NCBI:18104

Name
Email *

	Sorry, but the email address you supplied was invalid.