Napepld - N-acyl phosphatidylethanolamine phospholipase D Gene

Mus musculus

Also known as Mbldc1; NAPE-PLD; A530089G06

Gene ID: 242864 | Gene type: protein coding

About Napepld

Summary

Enables N-acylphosphatidylethanolamine-specific Phospholipase D activity. Involved in several processes, including N-acylphosphatidylethanolamine metabolic process; host-mediated regulation of intestinal microbiota composition; and positive regulation of brown fat cell differentiation. Acts upstream of or within N-acylethanolamine metabolic process. Predicted to be located in Golgi apparatus. Predicted to be active in cytoplasm and membrane-bounded organelle. Orthologous to human NAPEPLD (N-acyl phosphatidylethanolamine Phospholipase D). [provided by Alliance of Genome Resources, Apr 2022]

Napepld Products(4)

mRNA	Protein	Name
NM_001359963.1	NP_001346892.1	N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform b
NM_001359964.1	NP_001346893.1	N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform a
NM_001359965.1	NP_001346894.1	N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform b
NM_178728.6	NP_848843.1	N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables N-acylphosphatidylethanolamine-specific phospholipase D activity	IDA IDA: Inferred from direct assay	14634025	MGI
enables N-acylphosphatidylethanolamine-specific phospholipase D activity	IMP IMP: Inferred from mutant phenotype	16605240	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within N-acylethanolamine metabolic process	IDA IDA: Inferred from direct assay	14634025	MGI
acts upstream of or within N-acylethanolamine metabolic process	IMP IMP: Inferred from mutant phenotype	16818490	MGI
involved in N-acylphosphatidylethanolamine metabolic process	IDA IDA: Inferred from direct assay	15760304	MGI
involved in N-acylphosphatidylethanolamine metabolic process	IMP IMP: Inferred from mutant phenotype	16605240	MGI
involved in host-mediated regulation of intestinal microbiota composition	IMP IMP: Inferred from mutant phenotype	25757720	MGI
involved in positive regulation of brown fat cell differentiation	IMP IMP: Inferred from mutant phenotype	25757720	MGI
involved in positive regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	25757720	MGI
involved in temperature homeostasis	IMP IMP: Inferred from mutant phenotype	25757720	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in hippocampal mossy fiber to CA3 synapse	IDA IDA: Inferred from direct assay	18234884	MGI
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	24346263	MGI
is active in presynapse	IDA IDA: Inferred from direct assay	18234884	MGI
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	24346263	MGI
is active in smooth endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	18234884	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D

Metallo-beta-lactamase domain containing 1

NAPE-hydrolyzing phospholipase D

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-131181	LEI-401	Inhibitor	99.73%	Unkown
HY-155774	VU533		99.71%	Unkown
HY-118994	ARN19874	Inhibitor	99.54%	Unkown
HY-155773	VU534	Inhibitor	98.53%	Unkown
HY-RS09031	NAPEPLD Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS22012	Napepld Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Napepld	NCBI	NCBI:222236

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