Chga - chromogranin A Gene

Rattus norvegicus

Gene ID: 24258 | Gene type: protein coding

About Chga

Summary

Involved in several processes, including adenylate cyclase-activating Adrenergic Receptor signaling pathway involved in cardiac muscle relaxation; positive regulation of signal transduction; and regulation of blood circulation. Located in chromaffin granule; extracellular space; and neuronal dense core vesicle. Biomarker of hypertension. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; end stage renal disease; hypertension; and prostate Cancer. Orthologous to human CHGA (chromogranin A). [provided by Alliance of Genome Resources, Apr 2022]

Chga Products(1)

mRNA	Protein	Name
NM_021655.2	NP_067687.2	chromogranin-A precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12388744	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation	IDA IDA: Inferred from direct assay	22459152	RGD
involved in ovulation cycle	IEP IEP: Inferred from expression pattern	12873792	RGD
involved in positive regulation of cAMP/PKA signal transduction	IDA IDA: Inferred from direct assay	22459152	RGD
involved in positive regulation of cardiac muscle contraction	IDA IDA: Inferred from direct assay	22459152	RGD
involved in positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	11257446	RGD
involved in positive regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	22459152	RGD
involved in positive regulation of relaxation of cardiac muscle	IDA IDA: Inferred from direct assay	22459152	RGD
involved in positive regulation of vasoconstriction	IDA IDA: Inferred from direct assay	15544843	RGD
involved in regulation of cytosolic calcium ion concentration	IDA IDA: Inferred from direct assay	22459152	RGD
involved in regulation of the force of heart contraction	IDA IDA: Inferred from direct assay	22459152	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromaffin granule	IDA IDA: Inferred from direct assay	19372204	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	12873792	RGD
located in neuronal dense core vesicle	IDA IDA: Inferred from direct assay	29166604	RGD
located in secretory granule	IDA IDA: Inferred from direct assay	12388744	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

chromogranin-A

cgA	chromogranin A (parathyroid secretory protein 1)

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02624	CHGA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18918	Chga Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25408	Chga Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Chga	NCBI	NCBI:1113

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