Calm1 - calmodulin 1 Gene

Rattus norvegicus

Also known as CaMI; Calm; Cam1

Gene ID: 24242 | Gene type: protein coding

About Calm1

Summary

Enables several functions, including enzyme binding activity; transmembrane transporter binding activity; and type 3 metabotropic glutamate receptor binding activity. Involved in several processes, including activation of Adenylate Cyclase activity; regulation of calcium ion transmembrane transporter activity; and regulation of vesicle-mediated transport. Located in several cellular components, including growth cone; myelin sheath; and nucleus. Colocalizes with mitochondrial membrane and synaptic vesicle membrane. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in catecholaminergic polymorphic ventricular tachycardia 4; long QT syndrome 14; and long QT syndrome 15. Orthologous to several human genes including CALM1 (Calmodulin 1). [provided by Alliance of Genome Resources, Apr 2022]

Calm1 Products(1)

mRNA	Protein	Name
NM_031969.3	NP_114175.1	calmodulin-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium ion binding	IDA IDA: Inferred from direct assay	15628869	RGD
enables calcium-dependent protein binding	IPI IPI: Inferred from physical interaction	12032157	RGD
enables nitric-oxide synthase binding	IDA IDA: Inferred from direct assay	20529840	RGD
enables nitric-oxide synthase regulator activity	IDA IDA: Inferred from direct assay	20529840	RGD
enables phosphatidylinositol 3-kinase binding	IPI IPI: Inferred from physical interaction	17492691	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	11323678	RGD
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	21855531	RGD
enables transmembrane transporter binding	IDA IDA: Inferred from direct assay	15628869	RGD
enables type 3 metabotropic glutamate receptor binding	IPI IPI: Inferred from physical interaction	21855531	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in establishment of protein localization to membrane	IMP IMP: Inferred from mutant phenotype	23792689	RGD
involved in establishment of protein localization to mitochondrial membrane	IMP IMP: Inferred from mutant phenotype	23792689	RGD
involved in positive regulation of nitric-oxide synthase activity	IDA IDA: Inferred from direct assay	20529840	RGD
involved in regulation of high voltage-gated calcium channel activity	IMP IMP: Inferred from mutant phenotype	18322004	RGD
involved in regulation of ryanodine-sensitive calcium-release channel activity	IDA IDA: Inferred from direct assay	15628869	RGD
involved in regulation of synaptic vesicle endocytosis	IMP IMP: Inferred from mutant phenotype	23792689	RGD
involved in regulation of synaptic vesicle exocytosis	IMP IMP: Inferred from mutant phenotype	23792689	RGD
involved in response to amphetamine	IEP IEP: Inferred from expression pattern	10854758	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	22848456	RGD
located in growth cone	IDA IDA: Inferred from direct assay	7492944	RGD
located in mitochondrial membrane	IMP IMP: Inferred from mutant phenotype	23792689	RGD
located in myelin sheath	IDA IDA: Inferred from direct assay	19855925	RGD
is active in postsynaptic cytosol	IDA IDA: Inferred from direct assay	22848456	RGD
is active in presynaptic cytosol	IDA IDA: Inferred from direct assay	22848456	RGD
located in synaptic vesicle membrane	IMP IMP: Inferred from mutant phenotype	23792689	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

calmodulin-1

Calmodulin 1 (phosphorylase kinase, delta)	caM
calmodulin I

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01840	CALM1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS19989	Calm1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26493	Calm1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Calm1	NCBI	NCBI:801

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