2. Gene
  3. Cacna1c - calcium voltage-gated channel subunit alpha1 C Gene

Cacna1c - calcium voltage-gated channel subunit alpha1 C Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as RATIVS302

Gene ID: 24239 | Gene type: protein coding

About Cacna1c

Summary

Enables several functions, including high voltage-gated Calcium Channel activity; protein Phosphatase 2A binding activity; and transmembrane transporter binding activity. Involved in calcium ion transport; cellular response to amyloid-beta; and positive regulation of calcium ion transmembrane transport via high voltage-gated Calcium Channel. Located in several cellular components, including T-tubule; postsynaptic density; and synaptic membrane. Part of L-type voltage-gated Calcium Channel complex. Is active in glutamatergic synapse. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Colocalizes with Z disc. Human ortholog(s) of this gene implicated in Brugada syndrome 3 and Timothy syndrome. Orthologous to human CACNA1C (calcium voltage-gated channel subunit alpha1 C). [provided by Alliance of Genome Resources, Apr 2022]

Cacna1c Products(1)

mRNA Protein Name
NM_012517.2 NP_036649.2 voltage-dependent L-type calcium channel subunit alpha-1C
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables high voltage-gated calcium channel activity IDA
IDA: Inferred from direct assay
17068255 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
15140941 RGD
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
14569017 RGD
enables protein phosphatase 2A binding IPI
IPI: Inferred from physical interaction
16519540 RGD
enables translation initiation factor binding IPI
IPI: Inferred from physical interaction
23737983 RGD
enables transmembrane transporter binding IPI
IPI: Inferred from physical interaction
11576544 RGD
enables voltage-gated calcium channel activity IDA
IDA: Inferred from direct assay
15140941 RGD
enables voltage-gated calcium channel activity IMP
IMP: Inferred from mutant phenotype
16483597 RGD
Biological Process GO Annotation Evidence Reference Source
involved in axon development IEP
IEP: Inferred from expression pattern
22473424 RGD
involved in calcium ion import IMP
IMP: Inferred from mutant phenotype
19422800 RGD
involved in calcium ion transmembrane transport via high voltage-gated calcium channel IDA
IDA: Inferred from direct assay
15170217 RGD
involved in calcium ion transmembrane transport via high voltage-gated calcium channel IMP
IMP: Inferred from mutant phenotype
18562674 RGD
involved in calcium ion transport IMP
IMP: Inferred from mutant phenotype
16483597 RGD
involved in cellular response to amyloid-beta IEP
IEP: Inferred from expression pattern
21822937 RGD
involved in cerebral cortex development IEP
IEP: Inferred from expression pattern
22473424 RGD
involved in corpus callosum development IEP
IEP: Inferred from expression pattern
22473424 RGD
involved in exocytosis IMP
IMP: Inferred from mutant phenotype
18562674 RGD
involved in optic nerve development IEP
IEP: Inferred from expression pattern
22473424 RGD
involved in positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel IMP
IMP: Inferred from mutant phenotype
25675390 RGD
involved in positive regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
18562674 RGD
involved in positive regulation of membrane depolarization IMP
IMP: Inferred from mutant phenotype
18562674 RGD
involved in response to alcohol IEP
IEP: Inferred from expression pattern
27905406 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
20873977 RGD
involved in response to organic cyclic compound IDA
IDA: Inferred from direct assay
27905406 RGD
Cellular Component GO Annotation Evidence Reference Source
part of L-type voltage-gated calcium channel complex IDA
IDA: Inferred from direct assay
15170217 RGD
located in T-tubule IDA
IDA: Inferred from direct assay
14569017 RGD
located in Z disc IDA
IDA: Inferred from direct assay
11053140 RGD
located in axon IDA
IDA: Inferred from direct assay
22473424 RGD
located in cell surface IDA
IDA: Inferred from direct assay
21822937 RGD
located in dendrite IDA
IDA: Inferred from direct assay
15140941 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
18067152 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
15140941 RGD
NOT located in nucleus IDA
IDA: Inferred from direct assay
15140941 RGD
located in postsynaptic density IDA
IDA: Inferred from direct assay
15140941 RGD
is active in postsynaptic membrane IDA
IDA: Inferred from direct assay
18067152 RGD
NOT located in presynaptic membrane IDA
IDA: Inferred from direct assay
15140941 RGD
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
18067152 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
17068255 RGD
located in sarcolemma IDA
IDA: Inferred from direct assay
16483597 RGD
part of voltage-gated calcium channel complex IDA
IDA: Inferred from direct assay
16554304 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

voltage-dependent L-type calcium channel subunit alpha-1C

L-type calcium channel alpha-1 subunit

RBC

brain class C

calcium channel, voltage-dependent, L type, alpha 1C subunit

calcium channel, voltage-dependent, alpha 1C subunit

voltage-gated calcium channel subunit alpha Cav1.2

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01793 CACNA1C Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS21233 Cacna1c Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS27750 Cacna1c Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cacna1c NCBI NCBI:775