Atp7b - ATPase copper transporting beta Gene

Rattus norvegicus

Also known as Wd; Hts; PINA

Gene ID: 24218 | Gene type: protein coding

About Atp7b

Summary

Enables copper ion binding activity; copper ion transmembrane transporter activity; and zinc ion binding activity. Involved in several processes, including cellular response to metal ion; copper ion export; and lactation. Located in several cellular components, including basolateral plasma membrane; bicellular tight junction; and trans-Golgi network. Used to study Wilson disease; hepatitis; hepatocellular carcinoma; liver carcinoma; and renal adenoma. Human ortholog(s) of this gene implicated in Wilson disease. Orthologous to human ATP7B (ATPase copper transporting beta). [provided by Alliance of Genome Resources, Apr 2022]

Atp7b Products(1)

mRNA	Protein	Name
NM_012511.2	NP_036643.2	copper-transporting ATPase 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables copper ion binding	IDA IDA: Inferred from direct assay	14732483	RGD
enables copper ion transmembrane transporter activity	IDA IDA: Inferred from direct assay	9920665	RGD
enables zinc ion binding	IDA IDA: Inferred from direct assay	14732483	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to copper ion	IEP IEP: Inferred from expression pattern	24614235	RGD
involved in cellular response to copper ion	IMP IMP: Inferred from mutant phenotype	24614235	RGD
involved in cellular response to manganese ion	IEP IEP: Inferred from expression pattern	24614235	RGD
involved in circadian rhythm	IEP IEP: Inferred from expression pattern	9920665	RGD
involved in copper ion export	IMP IMP: Inferred from mutant phenotype	24614235	RGD
involved in lactation	IEP IEP: Inferred from expression pattern	16741141	RGD
involved in response to cAMP	IEP IEP: Inferred from expression pattern	9920665	RGD
involved in response to copper ion	IEP IEP: Inferred from expression pattern	15591161	RGD
involved in response to prolactin	IEP IEP: Inferred from expression pattern	16741141	RGD
involved in response to zinc ion	IEP IEP: Inferred from expression pattern	12840169	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical part of cell	IDA IDA: Inferred from direct assay	15994426	RGD
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	24614235	RGD
located in bicellular tight junction	IDA IDA: Inferred from direct assay	18395099	RGD
located in late endosome	IDA IDA: Inferred from direct assay	16741141	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	24614235	RGD
located in tight junction	IDA IDA: Inferred from direct assay	18395099	RGD
located in trans-Golgi network	IDA IDA: Inferred from direct assay	15994426	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

copper-transporting ATPase 2

ATPase, Cu++ transporting, beta polypeptide (same as Wilson disease)	PINA gene, promoter
copper pump 2	pineal night-specific ATPase
wilson disease-associated protein homolog

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01236	ATP7B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17601	Atp7b Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24061	Atp7b Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Atp7b	NCBI	NCBI:540

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