Aldob - aldolase, fructose-bisphosphate B Gene

Rattus norvegicus

Also known as Aldo2; LIV10

Gene ID: 24190 | Gene type: protein coding

About Aldob

Summary

Enables fructose-bisphosphate aldolase activity and phosphatidylcholine binding activity. Involved in several processes, including cellular response to Insulin stimulus; response to copper ion; and response to fructose. Located in several cellular components, including endoplasmic reticulum membrane; lysosome; and perinuclear region of cytoplasm. Used to study type 2 diabetes mellitus. Biomarker of liver benign neoplasm; peritonitis; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in hereditary fructose intolerance syndrome and type 2 diabetes mellitus. Orthologous to human ALDOB (aldolase, fructose-bisphosphate B). [provided by Alliance of Genome Resources, Apr 2022]

Aldob Products(1)

mRNA	Protein	Name
NM_012496.2	NP_036628.2	fructose-bisphosphate aldolase B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables fructose-bisphosphate aldolase activity	IDA IDA: Inferred from direct assay	9448062	RGD
enables phosphatidylcholine binding	IPI IPI: Inferred from physical interaction	9448062	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to insulin stimulus	IEP IEP: Inferred from expression pattern	9473304	RGD
involved in liver development	IEP IEP: Inferred from expression pattern	8641049	RGD
involved in response to amino acid	IEP IEP: Inferred from expression pattern	2984252	RGD
involved in response to cAMP	IEP IEP: Inferred from expression pattern	2984252	RGD
involved in response to carbohydrate	IEP IEP: Inferred from expression pattern	6689021	RGD
involved in response to copper ion	IEP IEP: Inferred from expression pattern	11044632	RGD
involved in response to fructose	IEP IEP: Inferred from expression pattern	2984252	RGD
involved in response to glucocorticoid	IEP IEP: Inferred from expression pattern	9473304	RGD
involved in response to interleukin-6	IEP IEP: Inferred from expression pattern	7625825	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	9020521	RGD
involved in response to peptide hormone	IDA IDA: Inferred from direct assay	10775441	RGD
involved in response to starvation	IEP IEP: Inferred from expression pattern	9886486	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	12387752	RGD
involved in response to zinc ion	IDA IDA: Inferred from direct assay	12721403	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	10797566	RGD
located in rough endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	234468	RGD
located in smooth endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	234468	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

fructose-bisphosphate aldolase B

Aldolase B, fructose-biphosphate	aldolase B, fructose-bisphosphate
liver-type aldolase

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00584	ALDOB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17969	Aldob Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24440	Aldob Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Aldob	NCBI	NCBI:229

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