2. Gene
  3. Acp2 - acid phosphatase 2, lysosomal Gene

Acp2 - acid phosphatase 2, lysosomal Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as LAP

Gene ID: 24162 | Gene type: protein coding

About Acp2

Summary

The protein encoded by this gene belongs to the histidine Acid Phosphatase family, which hydrolyze orthophosphoric monoesters to alcohol and phosphate. This protein is localized to the lysosomal membrane, and is chemically and genetically distinct from the red cell Acid Phosphatase. Mice lacking this gene showed multiple defects, including bone structure alterations, lysosomal storage defects, and an increased tendency towards seizures. An enzymatically-inactive allele of this gene showed severe growth retardation, hair-follicle abnormalities, and an ataxia-like phenotype. Two isoforms are predicted to be produced from the same mRNA by the use of alternative in-frame translation termination codons via a stop codon readthrough mechanism. [provided by RefSeq, Oct 2017]

Acp2 Products(2)

mRNA Protein Name
NM_001357071.1 NP_001344000.1 lysosomal acid phosphatase isoform 1x precursor
NM_016988.2 NP_058684.2 lysosomal acid phosphatase isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables acid phosphatase activity IDA
IDA: Inferred from direct assay
7827101 RGD
enables phosphoprotein phosphatase activity IDA
IDA: Inferred from direct assay
7686862 RGD
enables phosphotyrosine residue binding IDA
IDA: Inferred from direct assay
7686862 RGD
Biological Process GO Annotation Evidence Reference Source
involved in autophagic cell death IDA
IDA: Inferred from direct assay
18690537 RGD
involved in response to cGMP IDA
IDA: Inferred from direct assay
7827101 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

lysosomal acid phosphatase

Acid phosphatase 2, lysozymal

LMW-PTP-II low molecular weight phosphotyrosine protein phosphatase isozyme 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00187 ACP2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS22094 Acp2 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS28614 Acp2 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Acp2 NCBI NCBI:53