Zeb2 - zinc finger E-box binding homeobox 2 Gene

Mus musculus

Also known as SIP1; Zfx1b; Zfhx1b; Zfxh1b; 9130203F04Rik; D130016B08Rik

Gene ID: 24136 | Gene type: protein coding

About Zeb2

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and R-SMAD binding activity. Involved in several processes, including melanocyte migration; positive regulation of cell differentiation; and regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including nervous system development; neural crest cell migration; and positive regulation of signal transduction. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Used to study Mowat-Wilson syndrome and T-cell adult acute lymphocytic leukemia. Human ortholog(s) of this gene implicated in Hirschsprung's disease and Mowat-Wilson syndrome. Orthologous to human ZEB2 (zinc finger E-box binding homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]

Zeb2 Products(6)

mRNA	Protein	Name
NM_001289521.2	NP_001276450.1	zinc finger E-box-binding homeobox 2
NM_001355288.2	NP_001342217.1	zinc finger E-box-binding homeobox 2
NM_001355289.2	NP_001342218.1	zinc finger E-box-binding homeobox 2
NM_001355290.2	NP_001342219.1	zinc finger E-box-binding homeobox 2
NM_001355291.2	NP_001342220.1	zinc finger E-box-binding homeobox 2
NM_015753.5	NP_056568.2	zinc finger E-box-binding homeobox 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	25741725	MGI
enables R-SMAD binding	IDA IDA: Inferred from direct assay	16115198	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cell proliferation in forebrain	IMP IMP: Inferred from mutant phenotype	17644613	MGI
acts upstream of or within central nervous system development	IGI IGI: Inferred from genetic interaction	16598713	MGI
acts upstream of or within collateral sprouting	IMP IMP: Inferred from mutant phenotype	25741725	MGI
acts upstream of or within corpus callosum morphogenesis	IMP IMP: Inferred from mutant phenotype	25741725	MGI
acts upstream of or within corticospinal tract morphogenesis	IMP IMP: Inferred from mutant phenotype	25741725	MGI
involved in developmental pigmentation	IMP IMP: Inferred from mutant phenotype	24769727	MGI
acts upstream of or within embryonic morphogenesis	IGI IGI: Inferred from genetic interaction	16598713	MGI
acts upstream of or within hippocampus development	IMP IMP: Inferred from mutant phenotype	17644613	MGI
acts upstream of or within mammillary axonal complex development	IMP IMP: Inferred from mutant phenotype	25741725	MGI
involved in melanocyte migration	IMP IMP: Inferred from mutant phenotype	24769727	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	24769727	MGI
acts upstream of or within neural crest cell migration	IMP IMP: Inferred from mutant phenotype	12522767	MGI
acts upstream of or within neural tube closure	IMP IMP: Inferred from mutant phenotype	16598713	MGI
acts upstream of or within positive regulation of JUN kinase activity	IMP IMP: Inferred from mutant phenotype	17644613	MGI
acts upstream of or within positive regulation of Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	17644613	MGI
acts upstream of or within positive regulation of axonogenesis	IMP IMP: Inferred from mutant phenotype	25741725	MGI
involved in positive regulation of lens fiber cell differentiation	IMP IMP: Inferred from mutant phenotype	16162653	MGI
involved in positive regulation of melanocyte differentiation	IMP IMP: Inferred from mutant phenotype	24769727	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	25741725	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	24769727	MGI
involved in regulation of melanosome organization	IMP IMP: Inferred from mutant phenotype	24769727	MGI
acts upstream of or within somitogenesis	IMP IMP: Inferred from mutant phenotype	16157277	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	24769727	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

zinc finger E-box-binding homeobox 2

smad-interacting protein 1

zinc finger homeobox protein 1b

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-131445	RJW100	Activator	99.93%	Unkown
HY-173557	PRMT7-IN-2		/	Unkown
HY-RS16026	ZEB2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17821	Zeb2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24289	Zeb2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Zeb2	NCBI	NCBI:9839

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