Adamts4 - a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4 Gene

Mus musculus

Also known as ADMP-1; ADAM-TS4; ADAMTS-2

Gene ID: 240913 | Gene type: protein coding

About Adamts4

Summary

This gene encodes a member of "a disintegrin and metalloproteinase with thrombospondin motifs" (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. The encoded preproprotein undergoes proteolytic processing to generate an active zinc-dependent aggrecanase enzyme that degrades cartilage. [provided by RefSeq, Jul 2016]

Adamts4 Products(1)

mRNA	Protein	Name
NM_172845.3	NP_766433.2	A disintegrin and metalloproteinase with thrombospondin motifs 4 preproprotein

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables metalloendopeptidase activity	IDA IDA: Inferred from direct assay	23684986	MGI
enables metallopeptidase activity	IDA IDA: Inferred from direct assay	15192113	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	23684986	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within defense response to bacterium	IGI IGI: Inferred from genetic interaction	23684986	MGI
acts upstream of or within proteolysis	IDA IDA: Inferred from direct assay	15192113	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

A disintegrin and metalloproteinase with thrombospondin motifs 4

a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4

aggrecanase-1

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-137430	Aldumastat	Inhibitor	99.36%	Phase 2

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-101448	TMI-1		99.59%	Unkown
HY-145061	ADAMTS-5-IN-3	Inhibitor	98.89%	Unkown
HY-114996	ADAMTS-5 Inhibitor	Inhibitor	99.30%	Unkown
HY-P10398	5-FAM-TEGEARGSVILLK(5-TAMRA)K-NH2 TFA		92.55%	Unkown
HY-P5419A	WAAG-3R TFA		99.94%	Unkown
HY-P10468	5-FAM-TEGEARGSVILLK(5-TAMRA)K-NH2		/	Unkown
HY-RS00304	ADAMTS4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-160822	AGG-523	Inhibitor	/	Unkown
HY-RS18103	Adamts4 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24577	Adamts4 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Adamts4	NCBI	NCBI:9507

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