Sulf1 - sulfatase 1 Gene

Mus musculus

Also known as MSulf-1; mKIAA1077

Gene ID: 240725 | Gene type: protein coding

About Sulf1

Summary

Enables N-acetylglucosamine-6-sulfatase activity. Involved in several processes, including esophagus smooth muscle contraction; glomerular filtration; and skeletal system development. Located in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; limb; lower urogenital tract; and sensory organ. Orthologous to human SULF1 (sulfatase 1). [provided by Alliance of Genome Resources, Apr 2022]

Sulf1 Products(3)

mRNA	Protein	Name
NM_001198565.2	NP_001185494.1	extracellular sulfatase Sulf-1 precursor
NM_001198566.2	NP_001185495.1	extracellular sulfatase Sulf-1 precursor
NM_172294.2	NP_758498.1	extracellular sulfatase Sulf-1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables N-acetylglucosamine-6-sulfatase activity	IMP IMP: Inferred from mutant phenotype	18687675	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in bone development	IGI IGI: Inferred from genetic interaction	17593974	MGI
involved in cartilage development	IMP IMP: Inferred from mutant phenotype	20479257	MGI
involved in chondrocyte development	IMP IMP: Inferred from mutant phenotype	20479257	MGI
involved in embryonic skeletal system development	IGI IGI: Inferred from genetic interaction	18213582	MGI
involved in esophagus smooth muscle contraction	IGI IGI: Inferred from genetic interaction	17720696	MGI
involved in glial cell-derived neurotrophic factor receptor signaling pathway	IDA IDA: Inferred from direct assay	17720696	MGI
involved in glomerular basement membrane development	IGI IGI: Inferred from genetic interaction	21719793	MGI
involved in glomerular filtration	IGI IGI: Inferred from genetic interaction	21719793	MGI
involved in heparan sulfate proteoglycan metabolic process	IMP IMP: Inferred from mutant phenotype	18687675	MGI
involved in innervation	IGI IGI: Inferred from genetic interaction	17720696	MGI
involved in kidney development	IGI IGI: Inferred from genetic interaction	17593974	MGI
involved in negative regulation of fibroblast growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	20410206	MGI
involved in negative regulation of fibroblast growth factor receptor signaling pathway	IGI IGI: Inferred from genetic interaction	17593974	MGI
involved in negative regulation of prostatic bud formation	IDA IDA: Inferred from direct assay	20410206	MGI
involved in positive regulation of vascular endothelial growth factor production	IGI IGI: Inferred from genetic interaction	21719793	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	21719793	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

extracellular sulfatase Sulf-1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14011	SULF1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS19746	Sulf1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26243	Sulf1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sulf1	NCBI	NCBI:23213

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