Sufu - SUFU negative regulator of hedgehog signaling Gene

Mus musculus

Also known as Su(fu)

Gene ID: 24069 | Gene type: protein coding

About Sufu

Summary

Enables beta-catenin binding activity. Acts upstream of with a negative effect on smoothened signaling pathway. Acts upstream of or within several processes, including animal organ development; negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning; and regulation of transcription, DNA-templated. Located in cilium; cytoplasm; and nucleus. Is expressed in several structures, including alimentary system; central nervous system; limb; sensory organ; and testis. Used to study nevoid basal cell carcinoma syndrome. Human ortholog(s) of this gene implicated in Joubert syndrome 32; familial meningioma; medulloblastoma; and nevoid basal cell carcinoma syndrome. Orthologous to human SUFU (SUFU negative regulator of Hedgehog signaling). [provided by Alliance of Genome Resources, Apr 2022]

Sufu Products(2)

mRNA	Protein	Name
NM_001025391.2	NP_001020562.1	suppressor of fused homolog isoform 2
NM_015752.3	NP_056567.2	suppressor of fused homolog isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables beta-catenin binding	IDA IDA: Inferred from direct assay	11477086	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11252182	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within aorta development	IMP IMP: Inferred from mutant phenotype	25807483	MGI
acts upstream of or within coronary vasculature development	IMP IMP: Inferred from mutant phenotype	25807483	MGI
acts upstream of or within cytoplasmic sequestering of transcription factor	IGI IGI: Inferred from genetic interaction	16316410	MGI
acts upstream of or within determination of left/right symmetry	IMP IMP: Inferred from mutant phenotype	16155214	MGI
acts upstream of or within heart looping	IMP IMP: Inferred from mutant phenotype	16155214	MGI
acts upstream of or within negative regulation of smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	16459298	MGI
involved in negative regulation of smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	27234298	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16459298	MGI
acts upstream of or within negative regulation of ubiquitin-dependent protein catabolic process	IGI IGI: Inferred from genetic interaction	19684112	MGI
acts upstream of or within neural tube closure	IMP IMP: Inferred from mutant phenotype	16155214	MGI
acts upstream of or within skin development	IMP IMP: Inferred from mutant phenotype	16459298	MGI
acts upstream of smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	16459298	MGI
acts upstream of negative effect smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	29487109	MGI
acts upstream of or within smoothened signaling pathway involved in spinal cord motor neuron cell fate specification	IMP IMP: Inferred from mutant phenotype	19684112	MGI
acts upstream of or within smoothened signaling pathway involved in ventral spinal cord interneuron specification	IMP IMP: Inferred from mutant phenotype	19684112	MGI
acts upstream of or within spinal cord dorsal/ventral patterning	IMP IMP: Inferred from mutant phenotype	16459298	MGI
acts upstream of or within ventricular septum development	IMP IMP: Inferred from mutant phenotype	25807483	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cilium	IDA IDA: Inferred from direct assay	16254602	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	20360384	MGI
located in nucleus	IDA IDA: Inferred from direct assay	16254602	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

suppressor of fused homolog

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-105634A	Nomegestrol acetate	Agonist	99.94%	Yes

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-162273	Antibacterial agent 189	Inhibitor	/	Unkown
HY-RS14007	SUFU Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18155	Sufu Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24629	Sufu Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sufu	NCBI	NCBI:51684

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