Spry2 - sprouty RTK signaling antagonist 2 Gene

Mus musculus

Also known as sprouty2

Gene ID: 24064 | Gene type: protein coding

About Spry2

Summary

Predicted to enable protein kinase binding activity and protein serine/threonine kinase activator activity. Involved in several processes, including negative regulation of cell differentiation; negative regulation of cell projection organization; and negative regulation of signal transduction. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; lung development; and negative regulation of signal transduction. Located in several cellular components, including cytoskeleton; cytosol; and nucleus. Is expressed in several structures, including alimentary system; branchial arch; future brain; genitourinary system; and limb. Used to study achalasia and intestinal pseudo-obstruction. Human ortholog(s) of this gene implicated in IgA glomerulonephritis. Orthologous to human SPRY2 (sprouty RTK signaling antagonist 2). [provided by Alliance of Genome Resources, Apr 2022]

Spry2 Products(1)

mRNA	Protein	Name
NM_011897.3	NP_036027.1	protein sprouty homolog 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables molecular function inhibitor activity	IMP IMP: Inferred from mutant phenotype	15962011	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11585837	MGI
enables ubiquitin-protein transferase inhibitor activity	IMP IMP: Inferred from mutant phenotype	15962011	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of ERK1 and ERK2 cascade	IGI IGI: Inferred from genetic interaction	21764747	MGI
acts upstream of or within branching morphogenesis of an epithelial tube	IMP IMP: Inferred from mutant phenotype	10074434	MGI
acts upstream of or within bud elongation involved in lung branching	IGI IGI: Inferred from genetic interaction	21764747	MGI
acts upstream of or within cell fate commitment	IGI IGI: Inferred from genetic interaction	15809037	MGI
acts upstream of or within cell fate commitment	IMP IMP: Inferred from mutant phenotype	15809037	MGI
acts upstream of or within cellular response to leukemia inhibitory factor	IEP IEP: Inferred from expression pattern	20439489	MGI
acts upstream of or within establishment of mitotic spindle orientation	IGI IGI: Inferred from genetic interaction	21764747	MGI
acts upstream of fibroblast growth factor receptor signaling pathway	IGI IGI: Inferred from genetic interaction	15809037	MGI
acts upstream of or within inner ear morphogenesis	IGI IGI: Inferred from genetic interaction	15809037	MGI
acts upstream of or within inner ear morphogenesis	IMP IMP: Inferred from mutant phenotype	15809037	MGI
acts upstream of or within lung development	IMP IMP: Inferred from mutant phenotype	10074434	MGI
acts upstream of or within lung growth	IDA IDA: Inferred from direct assay	11287183	MGI
acts upstream of or within lung morphogenesis	IDA IDA: Inferred from direct assay	11287183	MGI
acts upstream of or within negative regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	11585837	MGI
involved in negative regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	18508928	MGI
acts upstream of or within negative regulation of ERK1 and ERK2 cascade	IGI IGI: Inferred from genetic interaction	21764747	MGI
acts upstream of or within negative regulation of GTPase activity	IDA IDA: Inferred from direct assay	11585837	MGI
acts upstream of or within negative regulation of MAP kinase activity	IDA IDA: Inferred from direct assay	16339969	MGI
acts upstream of or within negative regulation of Ras protein signal transduction	IDA IDA: Inferred from direct assay	11585837	MGI
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	18070883	MGI
acts upstream of or within negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	11585837	MGI
involved in negative regulation of cell projection organization	IDA IDA: Inferred from direct assay	18508928	MGI
involved in negative regulation of epithelial to mesenchymal transition	IDA IDA: Inferred from direct assay	25576668	MGI
acts upstream of or within negative regulation of fibroblast growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	11585837	MGI
acts upstream of or within negative regulation of fibroblast growth factor receptor signaling pathway	IGI IGI: Inferred from genetic interaction	15809037	MGI
involved in negative regulation of lens fiber cell differentiation	IDA IDA: Inferred from direct assay	29501879	MGI
acts upstream of or within negative regulation of neurotrophin TRK receptor signaling pathway	IDA IDA: Inferred from direct assay	11585837	MGI
involved in negative regulation of transforming growth factor beta receptor signaling pathway	IDA IDA: Inferred from direct assay	25576668	MGI
involved in positive regulation of epidermal growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	15962011	MGI
acts upstream of or within respiratory system development	IDA IDA: Inferred from direct assay	11287183	MGI
acts upstream of or within sensory perception of sound	IMP IMP: Inferred from mutant phenotype	15809037	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoskeleton	IDA IDA: Inferred from direct assay	18508928	MGI
located in cytosol	IDA IDA: Inferred from direct assay	18508928	MGI
located in membrane	IDA IDA: Inferred from direct assay	18508928	MGI
located in nucleus	IDA IDA: Inferred from direct assay	18508928	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein sprouty homolog 2

sprouty homolog 2

spry-2

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13722	SPRY2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22827	Spry2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29342	Spry2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Spry2	NCBI	NCBI:10253

Name
Email *

	Sorry, but the email address you supplied was invalid.