2. Gene
  3. Spry1 - sprouty RTK signaling antagonist 1 Gene

Spry1 - sprouty RTK signaling antagonist 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as spry-1; sprouty1

Gene ID: 24063 | Gene type: protein coding

About Spry1

Summary

Involved in negative regulation of cell differentiation and negative regulation of signal transduction. Acts upstream of or within several processes, including bud elongation involved in lung branching; kidney development; and negative regulation of signal transduction. Predicted to be located in Golgi apparatus and nucleoplasm. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; branchial arch; embryo ectoderm; limb; and sensory organ. Orthologous to human SPRY1 (sprouty RTK signaling antagonist 1). [provided by Alliance of Genome Resources, Apr 2022]

Spry1 Products(4)

mRNA Protein Name
NM_001305440.1 NP_001292369.1 protein sprouty homolog 1
NM_001305441.1 NP_001292370.1 protein sprouty homolog 1
NM_001305442.1 NP_001292371.1 protein sprouty homolog 1
NM_011896.3 NP_036026.1 protein sprouty homolog 1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16339969 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of ERK1 and ERK2 cascade IGI
IGI: Inferred from genetic interaction
21764747 MGI
acts upstream of or within bud elongation involved in lung branching IGI
IGI: Inferred from genetic interaction
21764747 MGI
acts upstream of or within establishment of mitotic spindle orientation IGI
IGI: Inferred from genetic interaction
21764747 MGI
acts upstream of or within metanephros development IGI
IGI: Inferred from genetic interaction
17537792 MGI
acts upstream of or within negative regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
11585837 MGI
involved in negative regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
29501879 MGI
acts upstream of or within negative regulation of ERK1 and ERK2 cascade IGI
IGI: Inferred from genetic interaction
21764747 MGI
involved in negative regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
19043405 MGI
acts upstream of or within negative regulation of GTPase activity IDA
IDA: Inferred from direct assay
11585837 MGI
acts upstream of or within negative regulation of MAP kinase activity IDA
IDA: Inferred from direct assay
16339969 MGI
acts upstream of or within negative regulation of Ras protein signal transduction IDA
IDA: Inferred from direct assay
11585837 MGI
acts upstream of or within negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
11585837 MGI
involved in negative regulation of epithelial to mesenchymal transition IDA
IDA: Inferred from direct assay
25576668 MGI
acts upstream of or within negative regulation of fibroblast growth factor receptor signaling pathway IDA
IDA: Inferred from direct assay
11585837 MGI
involved in negative regulation of lens fiber cell differentiation IDA
IDA: Inferred from direct assay
29501879 MGI
acts upstream of or within negative regulation of neurotrophin TRK receptor signaling pathway IDA
IDA: Inferred from direct assay
11585837 MGI
involved in negative regulation of transforming growth factor beta receptor signaling pathway IDA
IDA: Inferred from direct assay
25576668 MGI
acts upstream of or within organ induction IMP
IMP: Inferred from mutant phenotype
15691764 MGI
acts upstream of or within ureteric bud development IGI
IGI: Inferred from genetic interaction
15691764 MGI
acts upstream of or within ureteric bud development IMP
IMP: Inferred from mutant phenotype
15691764 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein sprouty homolog 1

inhibitor of receptor tyrosine kinases

sprouty homolog 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13721 SPRY1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS21767 Spry1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Spry1 NCBI NCBI:10252