2. Gene
  3. Mdc1 - mediator of DNA damage checkpoint 1 Gene

Mdc1 - mediator of DNA damage checkpoint 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Nfbd1; mKIAA0170; 6820401C03

Gene ID: 240087 | Gene type: protein coding

About Mdc1

Summary

The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 7 divergent copies of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. Mice with mutations in this gene exhibit growth retardation, male infertility, immune defects, chromosome instability, DNA repair defects, and radiation sensitivity. [provided by RefSeq, Jul 2008]

Mdc1 Products(10)

mRNA Protein Name
NM_001010833.2 NP_001010833.2 mediator of DNA damage checkpoint protein 1 isoform a
NM_001405521.1 NP_001392450.1 mediator of DNA damage checkpoint protein 1 isoform a
NM_001405522.1 NP_001392451.1 mediator of DNA damage checkpoint protein 1 isoform a
NM_001405523.1 NP_001392452.1 mediator of DNA damage checkpoint protein 1 isoform b
NM_001405524.1 NP_001392453.1 mediator of DNA damage checkpoint protein 1 isoform b
NM_001405525.1 NP_001392454.1 mediator of DNA damage checkpoint protein 1 isoform b
NM_001405526.1 NP_001392455.1 mediator of DNA damage checkpoint protein 1 isoform c
NM_001405527.1 NP_001392456.1 mediator of DNA damage checkpoint protein 1 isoform d
NM_001405528.1 NP_001392457.1 mediator of DNA damage checkpoint protein 1 isoform d
NM_001405529.1 NP_001392458.1 mediator of DNA damage checkpoint protein 1 isoform d
Gene Ontology
  • Cellular Component
Cellular Component GO Annotation Evidence Reference Source
located in chromosome IDA
IDA: Inferred from direct assay
23039116 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mediator of DNA damage checkpoint protein 1

mediation of DNA damage checkpoint 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08255 MDC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19917 Mdc1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26418 Mdc1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mdc1 NCBI NCBI:9656