2. Gene
  3. Slc26a4 - solute carrier family 26, member 4 Gene

Slc26a4 - solute carrier family 26, member 4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Pds; pendrin

Gene ID: 23985 | Gene type: protein coding

About Slc26a4

Summary

Predicted to enable anion transmembrane transporter activity. Involved in regulation of pH and regulation of protein localization. Located in apical plasma membrane and brush border membrane. Is expressed in central nervous system; cochlear duct; and metanephros. Used to study Pendred Syndrome. Human ortholog(s) of this gene implicated in Pendred Syndrome; autosomal recessive nonsyndromic deafness 4; and goiter. Orthologous to human SLC26A4 (solute carrier family 26 member 4). [provided by Alliance of Genome Resources, Apr 2022]

Slc26a4 Products(1)

mRNA Protein Name
NM_011867.4 NP_035997.1 pendrin
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables chloride:bicarbonate antiporter activity IDA
IDA: Inferred from direct assay
18565999 MGI
enables chloride:bicarbonate antiporter activity IMP
IMP: Inferred from mutant phenotype
11274445 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
35601831 MGI
Biological Process GO Annotation Evidence Reference Source
involved in regulation of pH IMP
IMP: Inferred from mutant phenotype
16144965 MGI
involved in regulation of protein localization IMP
IMP: Inferred from mutant phenotype
16144965 MGI
Cellular Component GO Annotation Evidence Reference Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
11274445 MGI
located in brush border membrane IDA
IDA: Inferred from direct assay
11459928 MGI
located in membrane IDA
IDA: Inferred from direct assay
17409310 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

pendrin

sodium-independent chloride/iodide transporter

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-159706 S9-A13 Inhibitor / Unkown
HY-168735 SLC26A4-IN-1 Inhibitor 99.68% Unkown
HY-RS13138 SLC26A4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21256 Slc26a4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27775 Slc26a4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc26a4 NCBI NCBI:5172